Cargando…
Response Inhibition and Interference Control in Obsessive–Compulsive Spectrum Disorders
Over the past 20 years, motor response inhibition and interference control have received considerable scientific effort and attention, due to their important role in behavior and the development of neuropsychiatric disorders. Results of neuroimaging studies indicate that motor response inhibition an...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052433/ https://www.ncbi.nlm.nih.gov/pubmed/24966828 http://dx.doi.org/10.3389/fnhum.2014.00419 |
_version_ | 1782320233001779200 |
---|---|
author | van Velzen, Laura S. Vriend, Chris de Wit, Stella J. van den Heuvel, Odile A. |
author_facet | van Velzen, Laura S. Vriend, Chris de Wit, Stella J. van den Heuvel, Odile A. |
author_sort | van Velzen, Laura S. |
collection | PubMed |
description | Over the past 20 years, motor response inhibition and interference control have received considerable scientific effort and attention, due to their important role in behavior and the development of neuropsychiatric disorders. Results of neuroimaging studies indicate that motor response inhibition and interference control are dependent on cortical–striatal–thalamic–cortical (CSTC) circuits. Structural and functional abnormalities within the CSTC circuits have been reported for many neuropsychiatric disorders, including obsessive–compulsive disorder (OCD) and related disorders, such as attention-deficit hyperactivity disorder, Tourette’s syndrome, and trichotillomania. These disorders also share impairments in motor response inhibition and interference control, which may underlie some of their behavioral and cognitive symptoms. Results of task-related neuroimaging studies on inhibitory functions in these disorders show that impaired task performance is related to altered recruitment of the CSTC circuits. Previous research has shown that inhibitory performance is dependent upon dopamine, noradrenaline, and serotonin signaling, neurotransmitters that have been implicated in the pathophysiology of these disorders. In this narrative review, we discuss the common and disorder-specific pathophysiological mechanisms of inhibition-related dysfunction in OCD and related disorders. |
format | Online Article Text |
id | pubmed-4052433 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-40524332014-06-25 Response Inhibition and Interference Control in Obsessive–Compulsive Spectrum Disorders van Velzen, Laura S. Vriend, Chris de Wit, Stella J. van den Heuvel, Odile A. Front Hum Neurosci Neuroscience Over the past 20 years, motor response inhibition and interference control have received considerable scientific effort and attention, due to their important role in behavior and the development of neuropsychiatric disorders. Results of neuroimaging studies indicate that motor response inhibition and interference control are dependent on cortical–striatal–thalamic–cortical (CSTC) circuits. Structural and functional abnormalities within the CSTC circuits have been reported for many neuropsychiatric disorders, including obsessive–compulsive disorder (OCD) and related disorders, such as attention-deficit hyperactivity disorder, Tourette’s syndrome, and trichotillomania. These disorders also share impairments in motor response inhibition and interference control, which may underlie some of their behavioral and cognitive symptoms. Results of task-related neuroimaging studies on inhibitory functions in these disorders show that impaired task performance is related to altered recruitment of the CSTC circuits. Previous research has shown that inhibitory performance is dependent upon dopamine, noradrenaline, and serotonin signaling, neurotransmitters that have been implicated in the pathophysiology of these disorders. In this narrative review, we discuss the common and disorder-specific pathophysiological mechanisms of inhibition-related dysfunction in OCD and related disorders. Frontiers Media S.A. 2014-06-11 /pmc/articles/PMC4052433/ /pubmed/24966828 http://dx.doi.org/10.3389/fnhum.2014.00419 Text en Copyright © 2014 van Velzen, Vriend, de Wit and van den Heuvel. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience van Velzen, Laura S. Vriend, Chris de Wit, Stella J. van den Heuvel, Odile A. Response Inhibition and Interference Control in Obsessive–Compulsive Spectrum Disorders |
title | Response Inhibition and Interference Control in Obsessive–Compulsive Spectrum Disorders |
title_full | Response Inhibition and Interference Control in Obsessive–Compulsive Spectrum Disorders |
title_fullStr | Response Inhibition and Interference Control in Obsessive–Compulsive Spectrum Disorders |
title_full_unstemmed | Response Inhibition and Interference Control in Obsessive–Compulsive Spectrum Disorders |
title_short | Response Inhibition and Interference Control in Obsessive–Compulsive Spectrum Disorders |
title_sort | response inhibition and interference control in obsessive–compulsive spectrum disorders |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052433/ https://www.ncbi.nlm.nih.gov/pubmed/24966828 http://dx.doi.org/10.3389/fnhum.2014.00419 |
work_keys_str_mv | AT vanvelzenlauras responseinhibitionandinterferencecontrolinobsessivecompulsivespectrumdisorders AT vriendchris responseinhibitionandinterferencecontrolinobsessivecompulsivespectrumdisorders AT dewitstellaj responseinhibitionandinterferencecontrolinobsessivecompulsivespectrumdisorders AT vandenheuvelodilea responseinhibitionandinterferencecontrolinobsessivecompulsivespectrumdisorders |