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Are Proteinase 3 and Cathepsin C Enzymes Related to Pathogenesis of Periodontitis?

Aim. Cathepsin C is the activator of the polymorphonuclear leukocyte-derived proteinase 3, which contributes to inflammatory processes. The aim of the present study was to investigate gingival crevicular fluid (GCF) proteinase 3 and cathepsin C levels in periodontal diseases. Design. Eighteen patien...

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Autores principales: Türkoğlu, Oya, Azarsız, Elif, Emingil, Gülnur, Kütükçüler, Necil, Atilla, Gül
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052470/
https://www.ncbi.nlm.nih.gov/pubmed/24949444
http://dx.doi.org/10.1155/2014/420830
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author Türkoğlu, Oya
Azarsız, Elif
Emingil, Gülnur
Kütükçüler, Necil
Atilla, Gül
author_facet Türkoğlu, Oya
Azarsız, Elif
Emingil, Gülnur
Kütükçüler, Necil
Atilla, Gül
author_sort Türkoğlu, Oya
collection PubMed
description Aim. Cathepsin C is the activator of the polymorphonuclear leukocyte-derived proteinase 3, which contributes to inflammatory processes. The aim of the present study was to investigate gingival crevicular fluid (GCF) proteinase 3 and cathepsin C levels in periodontal diseases. Design. Eighteen patients with chronic periodontitis (CP), 20 patients with generalized aggressive periodontitis (G-AgP), 20 patients with gingivitis, and 18 healthy subjects were included in the study. Periodontal parameters including probing depth, clinical attachment level, papilla bleeding index, and plaque index were assessed in all study subjects. GCF proteinase 3 and cathepsin C levels were analyzed by ELISA. Results. GCF proteinase 3 total amount was significantly higher in diseased groups compared to control group, after adjusting age (P < 0.05). No differences were found in GCF cathepsin C levels among the study groups (P > 0.05). Periodontal parameters of sampling sites were positively correlated with GCF proteinase 3 total amounts (P < 0.01) but not with cathepsin C total amounts (P > 0.05). Conclusions. Elevated levels of GCF proteinase 3 in CP, G-AgP, and gingivitis might suggest that proteinase 3 plays a role during inflammatory periodontal events in host response. However, cathepsin C in GCF does not seem to have an effect on the pathogenesis of periodontal diseases.
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spelling pubmed-40524702014-06-19 Are Proteinase 3 and Cathepsin C Enzymes Related to Pathogenesis of Periodontitis? Türkoğlu, Oya Azarsız, Elif Emingil, Gülnur Kütükçüler, Necil Atilla, Gül Biomed Res Int Research Article Aim. Cathepsin C is the activator of the polymorphonuclear leukocyte-derived proteinase 3, which contributes to inflammatory processes. The aim of the present study was to investigate gingival crevicular fluid (GCF) proteinase 3 and cathepsin C levels in periodontal diseases. Design. Eighteen patients with chronic periodontitis (CP), 20 patients with generalized aggressive periodontitis (G-AgP), 20 patients with gingivitis, and 18 healthy subjects were included in the study. Periodontal parameters including probing depth, clinical attachment level, papilla bleeding index, and plaque index were assessed in all study subjects. GCF proteinase 3 and cathepsin C levels were analyzed by ELISA. Results. GCF proteinase 3 total amount was significantly higher in diseased groups compared to control group, after adjusting age (P < 0.05). No differences were found in GCF cathepsin C levels among the study groups (P > 0.05). Periodontal parameters of sampling sites were positively correlated with GCF proteinase 3 total amounts (P < 0.01) but not with cathepsin C total amounts (P > 0.05). Conclusions. Elevated levels of GCF proteinase 3 in CP, G-AgP, and gingivitis might suggest that proteinase 3 plays a role during inflammatory periodontal events in host response. However, cathepsin C in GCF does not seem to have an effect on the pathogenesis of periodontal diseases. Hindawi Publishing Corporation 2014 2014-05-19 /pmc/articles/PMC4052470/ /pubmed/24949444 http://dx.doi.org/10.1155/2014/420830 Text en Copyright © 2014 Oya Türkoğlu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Türkoğlu, Oya
Azarsız, Elif
Emingil, Gülnur
Kütükçüler, Necil
Atilla, Gül
Are Proteinase 3 and Cathepsin C Enzymes Related to Pathogenesis of Periodontitis?
title Are Proteinase 3 and Cathepsin C Enzymes Related to Pathogenesis of Periodontitis?
title_full Are Proteinase 3 and Cathepsin C Enzymes Related to Pathogenesis of Periodontitis?
title_fullStr Are Proteinase 3 and Cathepsin C Enzymes Related to Pathogenesis of Periodontitis?
title_full_unstemmed Are Proteinase 3 and Cathepsin C Enzymes Related to Pathogenesis of Periodontitis?
title_short Are Proteinase 3 and Cathepsin C Enzymes Related to Pathogenesis of Periodontitis?
title_sort are proteinase 3 and cathepsin c enzymes related to pathogenesis of periodontitis?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052470/
https://www.ncbi.nlm.nih.gov/pubmed/24949444
http://dx.doi.org/10.1155/2014/420830
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