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Fentanyl and Spiradoline Interactions in a Place-Conditioning Black-White Shuttle-Box
Rats were trained for multiple sessions in a place-conditioning shuttle-box to explore motivational interactions of mu and kappa opioid agonists, specifically fentanyl reward and spiradoline aversion. In Phase 1, groups of rats received various doses of mu or kappa agonists, or placebo, testing for...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052544/ http://dx.doi.org/10.3390/ph401101 |
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author | Rech, Richard H. Briggs, Shannon L. Mokler, David J. |
author_facet | Rech, Richard H. Briggs, Shannon L. Mokler, David J. |
author_sort | Rech, Richard H. |
collection | PubMed |
description | Rats were trained for multiple sessions in a place-conditioning shuttle-box to explore motivational interactions of mu and kappa opioid agonists, specifically fentanyl reward and spiradoline aversion. In Phase 1, groups of rats received various doses of mu or kappa agonists, or placebo, testing for preference or aversion. Group A always received saline SC before 15-minute sessions. Group B received fentanyl SC (0.003, 0.006, 0.012 mg/kg), Group C received low and medium doses of agonists SC, and Group D received spiradoline (0.3, 0.6, 1.2 mg/kg) SC during Training Sessions 1-4, rats being restricted to the drug-associated compartment. Rats received saline when restricted to the placebo-associate compartment and on test days with access to both shuttle-box compartments. In Phase 2 of the study, Training Session 5, Combinations of mu and kappa agonists were substituted in Groups B, C, and D. Dose-related preference to fentanyl and aversion to spiradoline occurred during Test Sessions 1-4. During Test Session 5, fentanyl preference in Group B was suppressed by spiradoline, rats in Group C had a saline-like response to combined agonists, and spiradoline aversion in Group D was attenuated by fentanyl. These findings suggest that combined doses of mu and kappa agonists, while additive for antinociception, offset the rewarding and punishing effects of each other. |
format | Online Article Text |
id | pubmed-4052544 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-40525442014-06-11 Fentanyl and Spiradoline Interactions in a Place-Conditioning Black-White Shuttle-Box Rech, Richard H. Briggs, Shannon L. Mokler, David J. Pharmaceuticals (Basel) Article Rats were trained for multiple sessions in a place-conditioning shuttle-box to explore motivational interactions of mu and kappa opioid agonists, specifically fentanyl reward and spiradoline aversion. In Phase 1, groups of rats received various doses of mu or kappa agonists, or placebo, testing for preference or aversion. Group A always received saline SC before 15-minute sessions. Group B received fentanyl SC (0.003, 0.006, 0.012 mg/kg), Group C received low and medium doses of agonists SC, and Group D received spiradoline (0.3, 0.6, 1.2 mg/kg) SC during Training Sessions 1-4, rats being restricted to the drug-associated compartment. Rats received saline when restricted to the placebo-associate compartment and on test days with access to both shuttle-box compartments. In Phase 2 of the study, Training Session 5, Combinations of mu and kappa agonists were substituted in Groups B, C, and D. Dose-related preference to fentanyl and aversion to spiradoline occurred during Test Sessions 1-4. During Test Session 5, fentanyl preference in Group B was suppressed by spiradoline, rats in Group C had a saline-like response to combined agonists, and spiradoline aversion in Group D was attenuated by fentanyl. These findings suggest that combined doses of mu and kappa agonists, while additive for antinociception, offset the rewarding and punishing effects of each other. MDPI 2010-12-24 /pmc/articles/PMC4052544/ http://dx.doi.org/10.3390/ph401101 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Rech, Richard H. Briggs, Shannon L. Mokler, David J. Fentanyl and Spiradoline Interactions in a Place-Conditioning Black-White Shuttle-Box |
title | Fentanyl and Spiradoline Interactions in a Place-Conditioning Black-White Shuttle-Box |
title_full | Fentanyl and Spiradoline Interactions in a Place-Conditioning Black-White Shuttle-Box |
title_fullStr | Fentanyl and Spiradoline Interactions in a Place-Conditioning Black-White Shuttle-Box |
title_full_unstemmed | Fentanyl and Spiradoline Interactions in a Place-Conditioning Black-White Shuttle-Box |
title_short | Fentanyl and Spiradoline Interactions in a Place-Conditioning Black-White Shuttle-Box |
title_sort | fentanyl and spiradoline interactions in a place-conditioning black-white shuttle-box |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052544/ http://dx.doi.org/10.3390/ph401101 |
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