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Fentanyl and Spiradoline Interactions in a Place-Conditioning Black-White Shuttle-Box

Rats were trained for multiple sessions in a place-conditioning shuttle-box to explore motivational interactions of mu and kappa opioid agonists, specifically fentanyl reward and spiradoline aversion. In Phase 1, groups of rats received various doses of mu or kappa agonists, or placebo, testing for...

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Detalles Bibliográficos
Autores principales: Rech, Richard H., Briggs, Shannon L., Mokler, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052544/
http://dx.doi.org/10.3390/ph401101
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author Rech, Richard H.
Briggs, Shannon L.
Mokler, David J.
author_facet Rech, Richard H.
Briggs, Shannon L.
Mokler, David J.
author_sort Rech, Richard H.
collection PubMed
description Rats were trained for multiple sessions in a place-conditioning shuttle-box to explore motivational interactions of mu and kappa opioid agonists, specifically fentanyl reward and spiradoline aversion. In Phase 1, groups of rats received various doses of mu or kappa agonists, or placebo, testing for preference or aversion. Group A always received saline SC before 15-minute sessions. Group B received fentanyl SC (0.003, 0.006, 0.012 mg/kg), Group C received low and medium doses of agonists SC, and Group D received spiradoline (0.3, 0.6, 1.2 mg/kg) SC during Training Sessions 1-4, rats being restricted to the drug-associated compartment. Rats received saline when restricted to the placebo-associate compartment and on test days with access to both shuttle-box compartments. In Phase 2 of the study, Training Session 5, Combinations of mu and kappa agonists were substituted in Groups B, C, and D. Dose-related preference to fentanyl and aversion to spiradoline occurred during Test Sessions 1-4. During Test Session 5, fentanyl preference in Group B was suppressed by spiradoline, rats in Group C had a saline-like response to combined agonists, and spiradoline aversion in Group D was attenuated by fentanyl. These findings suggest that combined doses of mu and kappa agonists, while additive for antinociception, offset the rewarding and punishing effects of each other.
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spelling pubmed-40525442014-06-11 Fentanyl and Spiradoline Interactions in a Place-Conditioning Black-White Shuttle-Box Rech, Richard H. Briggs, Shannon L. Mokler, David J. Pharmaceuticals (Basel) Article Rats were trained for multiple sessions in a place-conditioning shuttle-box to explore motivational interactions of mu and kappa opioid agonists, specifically fentanyl reward and spiradoline aversion. In Phase 1, groups of rats received various doses of mu or kappa agonists, or placebo, testing for preference or aversion. Group A always received saline SC before 15-minute sessions. Group B received fentanyl SC (0.003, 0.006, 0.012 mg/kg), Group C received low and medium doses of agonists SC, and Group D received spiradoline (0.3, 0.6, 1.2 mg/kg) SC during Training Sessions 1-4, rats being restricted to the drug-associated compartment. Rats received saline when restricted to the placebo-associate compartment and on test days with access to both shuttle-box compartments. In Phase 2 of the study, Training Session 5, Combinations of mu and kappa agonists were substituted in Groups B, C, and D. Dose-related preference to fentanyl and aversion to spiradoline occurred during Test Sessions 1-4. During Test Session 5, fentanyl preference in Group B was suppressed by spiradoline, rats in Group C had a saline-like response to combined agonists, and spiradoline aversion in Group D was attenuated by fentanyl. These findings suggest that combined doses of mu and kappa agonists, while additive for antinociception, offset the rewarding and punishing effects of each other. MDPI 2010-12-24 /pmc/articles/PMC4052544/ http://dx.doi.org/10.3390/ph401101 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Rech, Richard H.
Briggs, Shannon L.
Mokler, David J.
Fentanyl and Spiradoline Interactions in a Place-Conditioning Black-White Shuttle-Box
title Fentanyl and Spiradoline Interactions in a Place-Conditioning Black-White Shuttle-Box
title_full Fentanyl and Spiradoline Interactions in a Place-Conditioning Black-White Shuttle-Box
title_fullStr Fentanyl and Spiradoline Interactions in a Place-Conditioning Black-White Shuttle-Box
title_full_unstemmed Fentanyl and Spiradoline Interactions in a Place-Conditioning Black-White Shuttle-Box
title_short Fentanyl and Spiradoline Interactions in a Place-Conditioning Black-White Shuttle-Box
title_sort fentanyl and spiradoline interactions in a place-conditioning black-white shuttle-box
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052544/
http://dx.doi.org/10.3390/ph401101
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