Cardiorenal Effects of Kappa Opioid Peptides During Ontogeny

This review focuses on the physiological roles for kappa opioid receptors (KORs) in adult animals and humans, as well as in the developing newborn animal. Our recent findings have provided new information that under physiological conditions in conscious newborn animals, activation of KORs with the s...

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Detalles Bibliográficos
Autores principales: Smith, Francine G., Qi, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052547/
http://dx.doi.org/10.3390/ph4010154
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author Smith, Francine G.
Qi, Wei
author_facet Smith, Francine G.
Qi, Wei
author_sort Smith, Francine G.
collection PubMed
description This review focuses on the physiological roles for kappa opioid receptors (KORs) in adult animals and humans, as well as in the developing newborn animal. Our recent findings have provided new information that under physiological conditions in conscious newborn animals, activation of KORs with the selective agonist, U-50488H, results in an aquaresis, as previously observed in adult animals and humans. In addition, we have shown in conscious lambs that KORs modulate systemic and renal haemodynamics as well as the arterial baroreflex control of heart rate, providing a previously unidentified role for KORs.
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spelling pubmed-40525472014-06-11 Cardiorenal Effects of Kappa Opioid Peptides During Ontogeny Smith, Francine G. Qi, Wei Pharmaceuticals (Basel) Review This review focuses on the physiological roles for kappa opioid receptors (KORs) in adult animals and humans, as well as in the developing newborn animal. Our recent findings have provided new information that under physiological conditions in conscious newborn animals, activation of KORs with the selective agonist, U-50488H, results in an aquaresis, as previously observed in adult animals and humans. In addition, we have shown in conscious lambs that KORs modulate systemic and renal haemodynamics as well as the arterial baroreflex control of heart rate, providing a previously unidentified role for KORs. MDPI 2011-01-11 /pmc/articles/PMC4052547/ http://dx.doi.org/10.3390/ph4010154 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Smith, Francine G.
Qi, Wei
Cardiorenal Effects of Kappa Opioid Peptides During Ontogeny
title Cardiorenal Effects of Kappa Opioid Peptides During Ontogeny
title_full Cardiorenal Effects of Kappa Opioid Peptides During Ontogeny
title_fullStr Cardiorenal Effects of Kappa Opioid Peptides During Ontogeny
title_full_unstemmed Cardiorenal Effects of Kappa Opioid Peptides During Ontogeny
title_short Cardiorenal Effects of Kappa Opioid Peptides During Ontogeny
title_sort cardiorenal effects of kappa opioid peptides during ontogeny
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052547/
http://dx.doi.org/10.3390/ph4010154
work_keys_str_mv AT smithfrancineg cardiorenaleffectsofkappaopioidpeptidesduringontogeny
AT qiwei cardiorenaleffectsofkappaopioidpeptidesduringontogeny

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