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Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells

The insulin/IGF-1 (insulin-like growth factor 1)-activated protein kinase Akt (also known as protein kinase B) phosphorylates Ser(487) in the ‘ST loop’ (serine/threonine-rich loop) within the C-terminal domain of AMPK-α1 (AMP-activated protein kinase-α1), leading to inhibition of phosphorylation by...

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Detalles Bibliográficos
Autores principales:	Hawley, Simon A., Ross, Fiona A., Gowans, Graeme J., Tibarewal, Priyanka, Leslie, Nicholas R., Hardie, D. Grahame
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052680/ https://www.ncbi.nlm.nih.gov/pubmed/24467442 http://dx.doi.org/10.1042/BJ20131344

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