Cargando…

MZB1 is a GRP94 cochaperone that enables proper immunoglobulin heavy chain biosynthesis upon ER stress

MZB1 (pERp1) is a B-cell-specific and endoplasmic reticulum (ER)-localized protein implicated in antibody secretion and integrin-mediated cell adhesion. Here, we examine the role of MZB1 in vivo by conditional gene inactivation in the mouse germline and at different stages of B lymphopoiesis. Deleti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rosenbaum, Marc, Andreani, Virginia, Kapoor, Tanya, Herp, Simone, Flach, Henrik, Duchniewicz, Marlena, Grosschedl, Rudolf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2014
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052763/ https://www.ncbi.nlm.nih.gov/pubmed/24888588 http://dx.doi.org/10.1101/gad.240762.114

Ejemplares similares

Cochaperone Mzb1 is a key effector of Blimp1 in plasma cell differentiation and β1-integrin function
por: Andreani, Virginia, et al.
Publicado: (2018)

MZB1 enables efficient interferon α secretion in stimulated plasmacytoid dendritic cells
por: Kapoor, Tanya, et al.
Publicado: (2020)

The endoplasmic reticulum chaperone BiP is a closure-accelerating cochaperone of Grp94
por: Huang, Bin, et al.
Publicado: (2022)

Structural Insights into Complexes of Glucose-Regulated Protein94 (Grp94) with Human Immunoglobulin G. Relevance for Grp94-IgG Complexes that Form In Vivo in Pathological Conditions
por: Pagetta, Andrea, et al.
Publicado: (2014)

Targeted Deletion of ER Chaperone GRP94 in the Liver Results in Injury, Repopulation of GRP94-Positive Hepatocytes, and Spontaneous Hepatocellular Carcinoma Development in Aged Mice
por: Chen, Wan-Ting, et al.
Publicado: (2014)

The clinical and prognostic evaluation of GRP94 immunoexpression in Caucasian patients with colorectal adenocarcinoma
por: Brzozowa-Zasada, Marlena, et al.
Publicado: (2019)

Differential requirement of GRP94 and GRP78 in mammary gland development
por: Zhu, Genyuan, et al.
Publicado: (2014)

Visualization of conformational transition of GRP94 in solution
por: Sun, Shangwu, et al.
Publicado: (2023)

GRP94 (gp96) and GRP94 N-Terminal Geldanamycin Binding Domain Elicit Tissue Nonrestricted Tumor Suppression
por: Baker-LePain, Julie C., et al.
Publicado: (2002)

Involvement of the Akt signaling pathway in ER-α36/GRP94-mediated signaling in gastric cancer
por: FU, ZHENGQI, et al.
Publicado: (2014)

Co-downregulation of GRP78 and GRP94 Induces Apoptosis and Inhibits Migration in Prostate Cancer Cells
por: Lu, Tong, et al.
Publicado: (2019)

GRP & love 94 present cool jazz and smooth vocals
Publicado: (1993)

Exploring the Functional Complementation between Grp94 and Hsp90
por: Maharaj, Kevin A., et al.
Publicado: (2016)

GRP94 Is Involved in the Lipid Phenotype of Brain Metastatic Cells
por: Santana-Codina, Naiara, et al.
Publicado: (2019)

Upregulation of Phosphorylated HSP27, PRDX2, GRP75, GRP78 and GRP94 in Acquired Middle Ear Cholesteatoma Growth
por: Ho, Kuen Yao, et al.
Publicado: (2013)

Valproate, a Mood Stabilizer, Induces WFS1 Expression and Modulates Its Interaction with ER Stress Protein GRP94
por: Kakiuchi, Chihiro, et al.
Publicado: (2009)

The HSP GRP94 interacts with macrophage intracellular complement C3 and impacts M2 profile during ER stress
por: Chaumonnot, Killian, et al.
Publicado: (2021)

MZB1 expression indicates poor prognosis in estrogen receptor-positive breast cancer
por: Watanabe, Manabu, et al.
Publicado: (2020)

Glucose-Regulated Protein 94 (GRP94): A Novel Regulator of Insulin-Like Growth Factor Production
por: Argon, Yair, et al.
Publicado: (2020)

OS-9 facilitates turnover of nonnative GRP94 marked by hyperglycosylation
por: Dersh, Devin, et al.
Publicado: (2014)

Molecular Chaperone GRP94/GP96 in Cancers: Oncogenesis and Therapeutic Target
por: Duan, Xiaofeng, et al.
Publicado: (2021)

Comprehensive analysis reveals GRP94 is associated with worse prognosis of breast cancer
por: Wang, Ting, et al.
Publicado: (2021)

Grp94 Inhibitor HCP1 Inhibits Human Dermal Fibroblast Senescence
por: Cui, Xiaoling, et al.
Publicado: (2022)

Alpha lipoic acid attenuates ER stress and improves glucose uptake through DNAJB3 cochaperone
por: Diane, Abdoulaye, et al.
Publicado: (2020)

The oncogenic role of the cochaperone Sgt1
por: Ogi, H, et al.
Publicado: (2015)

Increase of MZB1 in B cells in systemic lupus erythematosus: proteomic analysis of biopsied lymph nodes
por: Miyagawa-Hayashino, Aya, et al.
Publicado: (2018)

Expression and clinical significance of Glucose Regulated Proteins GRP78 (BiP) and GRP94 (GP96) in human adenocarcinomas of the esophagus
por: Langer, Rupert, et al.
Publicado: (2008)

Overexpression of molecular chaperons GRP78 and GRP94 in CD44(hi)/CD24(lo) breast cancer stem cells
por: Nami, Babak, et al.
Publicado: (2016)

Grp94 acts as a mediator of curcumin-induced antioxidant defence in myogenic cells
por: Pizzo, Paola, et al.
Publicado: (2010)

Clinicopathologic and Prognostic Association of GRP94 Expression in Colorectal Cancer with Synchronous and Metachronous Metastases
por: Yun, Sumi, et al.
Publicado: (2021)

Decreased functional expression of Grp78 and Grp94 inhibits proliferation and attenuates apoptosis in a human gastric cancer cell line in vitro
por: ZHANG, XINCHEN, et al.
Publicado: (2015)

Molecular Cochaperones: Tumor Growth and Cancer Treatment
por: Calderwood, Stuart K.
Publicado: (2013)

Hepatic Overexpression of GRP94 in a Rabbit Model of Parenteral Nutrition-Associated Liver Disease
por: Zhu, Xueping, et al.
Publicado: (2015)

Overexpression of molecule GRP94 favors tumor progression in lung adenocarcinoma by interaction with regulatory T cells
por: Duan, Xiao‐Feng, et al.
Publicado: (2020)

FBXL2 counteracts Grp94 to destabilize EGFR and inhibit EGFR-driven NSCLC growth
por: Niu, Mengmeng, et al.
Publicado: (2021)

Pharmacological Targeting of the ER-Resident Chaperones GRP94 or Cyclophilin B Induces Secretion of IL-22 Binding Protein Isoform-1 (IL-22BPi1)
por: Gómez-Fernández, Paloma, et al.
Publicado: (2019)

Crucial role of HSP90 in the Akt-dependent promotion of angiogenic-like effect of glucose-regulated protein94 (Grp94)-IgG complexes
por: Tramentozzi, Elisa, et al.
Publicado: (2011)

Targeted Mutation of the Mouse Grp94 Gene Disrupts Development and Perturbs Endoplasmic Reticulum Stress Signaling
por: Mao, Changhui, et al.
Publicado: (2010)

Proteomic Investigation on Grp94-IgG Complexes Circulating in Plasma of Type 1 Diabetic Subjects
por: Roveri, Antonella, et al.
Publicado: (2015)

Cell Surface GRP94 as a Novel Emerging Therapeutic Target for Monoclonal Antibody Cancer Therapy
por: Kim, Ji Woong, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_kilaqm47dv2c6aun4dmfk90jvn