Primary extranodal NK/T cell lymphoma, nasal-type of uterus with adenomyosis: a case report

Natural killer (NK)/T cell lymphoma of the female genital tract is extremely rare. We here report a case of ‘nasal type’ NK/T cell lymphoma arising in the uterus with adenomyosis in a 41-year-old woman with fever and hypogastralgia. The histologic analysis demonstrated a highly aggressive tumor with...

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Detalles Bibliográficos
Autores principales: Fang, Jian-chen, Zhou, Jue, Li, Zheng, Xia, Zhao-xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052815/
https://www.ncbi.nlm.nih.gov/pubmed/24886075
http://dx.doi.org/10.1186/1746-1596-9-95
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author Fang, Jian-chen
Zhou, Jue
Li, Zheng
Xia, Zhao-xia
author_facet Fang, Jian-chen
Zhou, Jue
Li, Zheng
Xia, Zhao-xia
author_sort Fang, Jian-chen
collection PubMed
description Natural killer (NK)/T cell lymphoma of the female genital tract is extremely rare. We here report a case of ‘nasal type’ NK/T cell lymphoma arising in the uterus with adenomyosis in a 41-year-old woman with fever and hypogastralgia. The histologic analysis demonstrated a highly aggressive tumor with characteristic angiocentric/angiodestructive growth pattern and focal necrosis. The lymphoma cells displayed a CD3ϵ/CD56/TIA-1/granzyme-B/Perforin-positive and CD20/CD79a/CD4/CD8-negative immunophenotype and positive for Epstein-Barr virus by EBER in situ hybridization. Clinically, the disease was limited to the uterus at the initial diagnosis, but progressed rapidly. The patient died on day 54 after hysterectomy, irrespective of intensive chemotherapy. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1323474831125945
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spelling pubmed-40528152014-06-12 Primary extranodal NK/T cell lymphoma, nasal-type of uterus with adenomyosis: a case report Fang, Jian-chen Zhou, Jue Li, Zheng Xia, Zhao-xia Diagn Pathol Case Report Natural killer (NK)/T cell lymphoma of the female genital tract is extremely rare. We here report a case of ‘nasal type’ NK/T cell lymphoma arising in the uterus with adenomyosis in a 41-year-old woman with fever and hypogastralgia. The histologic analysis demonstrated a highly aggressive tumor with characteristic angiocentric/angiodestructive growth pattern and focal necrosis. The lymphoma cells displayed a CD3ϵ/CD56/TIA-1/granzyme-B/Perforin-positive and CD20/CD79a/CD4/CD8-negative immunophenotype and positive for Epstein-Barr virus by EBER in situ hybridization. Clinically, the disease was limited to the uterus at the initial diagnosis, but progressed rapidly. The patient died on day 54 after hysterectomy, irrespective of intensive chemotherapy. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1323474831125945 BioMed Central 2014-05-23 /pmc/articles/PMC4052815/ /pubmed/24886075 http://dx.doi.org/10.1186/1746-1596-9-95 Text en Copyright © 2014 Fang et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Fang, Jian-chen
Zhou, Jue
Li, Zheng
Xia, Zhao-xia
Primary extranodal NK/T cell lymphoma, nasal-type of uterus with adenomyosis: a case report
title Primary extranodal NK/T cell lymphoma, nasal-type of uterus with adenomyosis: a case report
title_full Primary extranodal NK/T cell lymphoma, nasal-type of uterus with adenomyosis: a case report
title_fullStr Primary extranodal NK/T cell lymphoma, nasal-type of uterus with adenomyosis: a case report
title_full_unstemmed Primary extranodal NK/T cell lymphoma, nasal-type of uterus with adenomyosis: a case report
title_short Primary extranodal NK/T cell lymphoma, nasal-type of uterus with adenomyosis: a case report
title_sort primary extranodal nk/t cell lymphoma, nasal-type of uterus with adenomyosis: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052815/
https://www.ncbi.nlm.nih.gov/pubmed/24886075
http://dx.doi.org/10.1186/1746-1596-9-95
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