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Glycyrrhizic Acid in the Treatment of Liver Diseases: Literature Review

Glycyrrhizic acid (GA) is a triterpene glycoside found in the roots of licorice plants (Glycyrrhiza glabra). GA is the most important active ingredient in the licorice root, and possesses a wide range of pharmacological and biological activities. GA coupled with glycyrrhetinic acid and 18-beta-glycy...

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Autores principales: Li, Jian-yuan, Cao, Hong-yan, Liu, Ping, Cheng, Gen-hong, Sun, Ming-yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052927/
https://www.ncbi.nlm.nih.gov/pubmed/24963489
http://dx.doi.org/10.1155/2014/872139
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author Li, Jian-yuan
Cao, Hong-yan
Liu, Ping
Cheng, Gen-hong
Sun, Ming-yu
author_facet Li, Jian-yuan
Cao, Hong-yan
Liu, Ping
Cheng, Gen-hong
Sun, Ming-yu
author_sort Li, Jian-yuan
collection PubMed
description Glycyrrhizic acid (GA) is a triterpene glycoside found in the roots of licorice plants (Glycyrrhiza glabra). GA is the most important active ingredient in the licorice root, and possesses a wide range of pharmacological and biological activities. GA coupled with glycyrrhetinic acid and 18-beta-glycyrrhetic acid was developed in China or Japan as an anti-inflammatory, antiviral, and antiallergic drug for liver disease. This review summarizes the current biological activities of GA and its medical applications in liver diseases. The pharmacological actions of GA include inhibition of hepatic apoptosis and necrosis; anti-inflammatory and immune regulatory actions; antiviral effects; and antitumor effects. This paper will be a useful reference for physicians and biologists researching GA and will open the door to novel agents in drug discovery and development from Chinese herbs. With additional research, GA may be more widely used in the treatment of liver diseases or other conditions.
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spelling pubmed-40529272014-06-24 Glycyrrhizic Acid in the Treatment of Liver Diseases: Literature Review Li, Jian-yuan Cao, Hong-yan Liu, Ping Cheng, Gen-hong Sun, Ming-yu Biomed Res Int Review Article Glycyrrhizic acid (GA) is a triterpene glycoside found in the roots of licorice plants (Glycyrrhiza glabra). GA is the most important active ingredient in the licorice root, and possesses a wide range of pharmacological and biological activities. GA coupled with glycyrrhetinic acid and 18-beta-glycyrrhetic acid was developed in China or Japan as an anti-inflammatory, antiviral, and antiallergic drug for liver disease. This review summarizes the current biological activities of GA and its medical applications in liver diseases. The pharmacological actions of GA include inhibition of hepatic apoptosis and necrosis; anti-inflammatory and immune regulatory actions; antiviral effects; and antitumor effects. This paper will be a useful reference for physicians and biologists researching GA and will open the door to novel agents in drug discovery and development from Chinese herbs. With additional research, GA may be more widely used in the treatment of liver diseases or other conditions. Hindawi Publishing Corporation 2014 2014-05-13 /pmc/articles/PMC4052927/ /pubmed/24963489 http://dx.doi.org/10.1155/2014/872139 Text en Copyright © 2014 Jian-yuan Li et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Li, Jian-yuan
Cao, Hong-yan
Liu, Ping
Cheng, Gen-hong
Sun, Ming-yu
Glycyrrhizic Acid in the Treatment of Liver Diseases: Literature Review
title Glycyrrhizic Acid in the Treatment of Liver Diseases: Literature Review
title_full Glycyrrhizic Acid in the Treatment of Liver Diseases: Literature Review
title_fullStr Glycyrrhizic Acid in the Treatment of Liver Diseases: Literature Review
title_full_unstemmed Glycyrrhizic Acid in the Treatment of Liver Diseases: Literature Review
title_short Glycyrrhizic Acid in the Treatment of Liver Diseases: Literature Review
title_sort glycyrrhizic acid in the treatment of liver diseases: literature review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052927/
https://www.ncbi.nlm.nih.gov/pubmed/24963489
http://dx.doi.org/10.1155/2014/872139
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