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Pharmacologic reversion of epigenetic silencing of the PRKD1 promoter blocks breast tumor cell invasion and metastasis

INTRODUCTION: DNA methylation-induced silencing of genes encoding tumor suppressors is common in many types of cancer, but little is known about how such epigenetic silencing can contribute to tumor metastasis. The PRKD1 gene encodes protein kinase D1 (PKD1), a serine/threonine kinase that is expres...

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Detalles Bibliográficos
Autores principales:	Borges, Sahra, Döppler, Heike, Perez, Edith A, Andorfer, Cathy A, Sun, Zhifu, Anastasiadis, Panos Z, Thompson, E Aubrey, Geiger, Xochiquetzal J, Storz, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052945/ https://www.ncbi.nlm.nih.gov/pubmed/23971832 http://dx.doi.org/10.1186/bcr3460

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