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Hypoxia and Reoxygenation Induce Endothelial Nitric Oxide Synthase Uncoupling in Endothelial Cells through Tetrahydrobiopterin Depletion and S-Glutathionylation

[Image: see text] Ischemia-reperfusion injury is accompanied by endothelial hypoxia and reoxygenation that trigger oxidative stress with enhanced superoxide generation and diminished nitric oxide (NO) production leading to endothelial dysfunction. Oxidative depletion of the endothelial NO synthase (...

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Detalles Bibliográficos
Autores principales:	De Pascali, Francesco, Hemann, Craig, Samons, Kindra, Chen, Chun-An, Zweier, Jay L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053070/ https://www.ncbi.nlm.nih.gov/pubmed/24758136 http://dx.doi.org/10.1021/bi500076r

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