A BRCA1 deficient-like signature is enriched in breast cancer brain metastases and predicts DNA damage-induced poly (ADP-ribose) polymerase inhibitor sensitivity

INTRODUCTION: There is an unmet clinical need for biomarkers to identify breast cancer patients at an increased risk of developing brain metastases. The objective is to identify gene signatures and biological pathways associated with human epidermal growth factor receptor 2-positive (HER2+) brain me...

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Detalles Bibliográficos
Autores principales: McMullin, Ryan P, Wittner, Ben S, Yang, Chuanwei, Denton-Schneider, Benjamin R, Hicks, Daniel, Singavarapu, Raj, Moulis, Sharon, Lee, Jeongeun, Akbari, Mohammad R, Narod, Steven A, Aldape, Kenneth D, Steeg, Patricia S, Ramaswamy, Sridhar, Sgroi, Dennis C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053087/
https://www.ncbi.nlm.nih.gov/pubmed/24625110
http://dx.doi.org/10.1186/bcr3625

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