Patient-derived xenografts of triple-negative breast cancer reproduce molecular features of patient tumors and respond to mTOR inhibition

INTRODUCTION: Triple-negative breast cancer (TNBC) is aggressive and lacks targeted therapies. Phosphatidylinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) pathways are frequently activated in TNBC patient tumors at the genome, gene expression and protein levels, and mTOR inhibitors ha...

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Detalles Bibliográficos
Autores principales: Zhang, Haiyu, Cohen, Adam L, Krishnakumar, Sujatha, Wapnir, Irene L, Veeriah, Selvaraju, Deng, Glenn, Coram, Marc A, Piskun, Caroline M, Longacre, Teri A, Herrler, Michael, Frimannsson, Daniel O, Telli, Melinda L, Dirbas, Frederick M, Matin, AC, Dairkee, Shanaz H, Larijani, Banafshe, Glinsky, Gennadi V, Bild, Andrea H, Jeffrey, Stefanie S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053092/
https://www.ncbi.nlm.nih.gov/pubmed/24708766
http://dx.doi.org/10.1186/bcr3640

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