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Retinoids and breast cancer: new clues to increase their activity and selectivity
All-trans retinoic acid and derivatives (retinoids) are promising agents in the management of certain hematologic malignancies and solid tumors, including breast cancer. Retinoids are endowed with anti-proliferative, cyto-differentiating and apoptotic effects that are largely mediated by activation...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053099/ https://www.ncbi.nlm.nih.gov/pubmed/22992337 http://dx.doi.org/10.1186/bcr3245 |
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author | Garattini, Enrico Paroni, Gabriela Terao, Mineko |
author_facet | Garattini, Enrico Paroni, Gabriela Terao, Mineko |
author_sort | Garattini, Enrico |
collection | PubMed |
description | All-trans retinoic acid and derivatives (retinoids) are promising agents in the management of certain hematologic malignancies and solid tumors, including breast cancer. Retinoids are endowed with anti-proliferative, cyto-differentiating and apoptotic effects that are largely mediated by activation of the nuclear hormone retinoic acid receptors RARα, RARβ and RARγ. These are ligand-dependent transcriptional factors controlling the expression of numerous genes. The relative importance of each receptor subtype for the anti-tumor activity of retinoids is largely unknown. Clarification of this point is of fundamental importance for the rational design of retinoid-based therapeutic approaches aimed at controlling a heterogeneous type of tumors, like breast cancer. |
format | Online Article Text |
id | pubmed-4053099 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-40530992014-06-12 Retinoids and breast cancer: new clues to increase their activity and selectivity Garattini, Enrico Paroni, Gabriela Terao, Mineko Breast Cancer Res Editorial All-trans retinoic acid and derivatives (retinoids) are promising agents in the management of certain hematologic malignancies and solid tumors, including breast cancer. Retinoids are endowed with anti-proliferative, cyto-differentiating and apoptotic effects that are largely mediated by activation of the nuclear hormone retinoic acid receptors RARα, RARβ and RARγ. These are ligand-dependent transcriptional factors controlling the expression of numerous genes. The relative importance of each receptor subtype for the anti-tumor activity of retinoids is largely unknown. Clarification of this point is of fundamental importance for the rational design of retinoid-based therapeutic approaches aimed at controlling a heterogeneous type of tumors, like breast cancer. BioMed Central 2012 2012-09-04 /pmc/articles/PMC4053099/ /pubmed/22992337 http://dx.doi.org/10.1186/bcr3245 Text en Copyright © 2012 BioMed Central Ltd |
spellingShingle | Editorial Garattini, Enrico Paroni, Gabriela Terao, Mineko Retinoids and breast cancer: new clues to increase their activity and selectivity |
title | Retinoids and breast cancer: new clues to increase their activity and selectivity |
title_full | Retinoids and breast cancer: new clues to increase their activity and selectivity |
title_fullStr | Retinoids and breast cancer: new clues to increase their activity and selectivity |
title_full_unstemmed | Retinoids and breast cancer: new clues to increase their activity and selectivity |
title_short | Retinoids and breast cancer: new clues to increase their activity and selectivity |
title_sort | retinoids and breast cancer: new clues to increase their activity and selectivity |
topic | Editorial |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053099/ https://www.ncbi.nlm.nih.gov/pubmed/22992337 http://dx.doi.org/10.1186/bcr3245 |
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