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Retinoids and breast cancer: new clues to increase their activity and selectivity

All-trans retinoic acid and derivatives (retinoids) are promising agents in the management of certain hematologic malignancies and solid tumors, including breast cancer. Retinoids are endowed with anti-proliferative, cyto-differentiating and apoptotic effects that are largely mediated by activation...

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Detalles Bibliográficos
Autores principales: Garattini, Enrico, Paroni, Gabriela, Terao, Mineko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053099/
https://www.ncbi.nlm.nih.gov/pubmed/22992337
http://dx.doi.org/10.1186/bcr3245
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author Garattini, Enrico
Paroni, Gabriela
Terao, Mineko
author_facet Garattini, Enrico
Paroni, Gabriela
Terao, Mineko
author_sort Garattini, Enrico
collection PubMed
description All-trans retinoic acid and derivatives (retinoids) are promising agents in the management of certain hematologic malignancies and solid tumors, including breast cancer. Retinoids are endowed with anti-proliferative, cyto-differentiating and apoptotic effects that are largely mediated by activation of the nuclear hormone retinoic acid receptors RARα, RARβ and RARγ. These are ligand-dependent transcriptional factors controlling the expression of numerous genes. The relative importance of each receptor subtype for the anti-tumor activity of retinoids is largely unknown. Clarification of this point is of fundamental importance for the rational design of retinoid-based therapeutic approaches aimed at controlling a heterogeneous type of tumors, like breast cancer.
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spelling pubmed-40530992014-06-12 Retinoids and breast cancer: new clues to increase their activity and selectivity Garattini, Enrico Paroni, Gabriela Terao, Mineko Breast Cancer Res Editorial All-trans retinoic acid and derivatives (retinoids) are promising agents in the management of certain hematologic malignancies and solid tumors, including breast cancer. Retinoids are endowed with anti-proliferative, cyto-differentiating and apoptotic effects that are largely mediated by activation of the nuclear hormone retinoic acid receptors RARα, RARβ and RARγ. These are ligand-dependent transcriptional factors controlling the expression of numerous genes. The relative importance of each receptor subtype for the anti-tumor activity of retinoids is largely unknown. Clarification of this point is of fundamental importance for the rational design of retinoid-based therapeutic approaches aimed at controlling a heterogeneous type of tumors, like breast cancer. BioMed Central 2012 2012-09-04 /pmc/articles/PMC4053099/ /pubmed/22992337 http://dx.doi.org/10.1186/bcr3245 Text en Copyright © 2012 BioMed Central Ltd
spellingShingle Editorial
Garattini, Enrico
Paroni, Gabriela
Terao, Mineko
Retinoids and breast cancer: new clues to increase their activity and selectivity
title Retinoids and breast cancer: new clues to increase their activity and selectivity
title_full Retinoids and breast cancer: new clues to increase their activity and selectivity
title_fullStr Retinoids and breast cancer: new clues to increase their activity and selectivity
title_full_unstemmed Retinoids and breast cancer: new clues to increase their activity and selectivity
title_short Retinoids and breast cancer: new clues to increase their activity and selectivity
title_sort retinoids and breast cancer: new clues to increase their activity and selectivity
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053099/
https://www.ncbi.nlm.nih.gov/pubmed/22992337
http://dx.doi.org/10.1186/bcr3245
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