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NOTCH1 inhibition in vivo results in mammary tumor regression and reduced mammary tumorsphere-forming activity in vitro

INTRODUCTION: NOTCH activation has been recently implicated in human breast cancers, associated with a poor prognosis, and tumor-initiating cells are hypothesized to mediate resistance to treatment and disease relapse. To address the role of NOTCH1 in mammary gland development, transformation, and m...

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Detalles Bibliográficos
Autores principales:	Simmons, Matthew J, Serra, Ryan, Hermance, Nicole, Kelliher, Michelle A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053103/ https://www.ncbi.nlm.nih.gov/pubmed/22992387 http://dx.doi.org/10.1186/bcr3321

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