Cargando…

NOTCH1 inhibition in vivo results in mammary tumor regression and reduced mammary tumorsphere-forming activity in vitro

INTRODUCTION: NOTCH activation has been recently implicated in human breast cancers, associated with a poor prognosis, and tumor-initiating cells are hypothesized to mediate resistance to treatment and disease relapse. To address the role of NOTCH1 in mammary gland development, transformation, and m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Simmons, Matthew J, Serra, Ryan, Hermance, Nicole, Kelliher, Michelle A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053103/ https://www.ncbi.nlm.nih.gov/pubmed/22992387 http://dx.doi.org/10.1186/bcr3321

Ejemplares similares

Notch3 marks clonogenic mammary luminal progenitor cells in vivo
por: Lafkas, Daniel, et al.
Publicado: (2013)

Differentiation of mammary stem cells in vivo and in vitro.
por: Barraclough, R, et al.
Publicado: (1989)

Mammary extracellular matrix directs differentiation of testicular and embryonic stem cells to form functional mammary glands in vivo
por: Bruno, Robert D., et al.
Publicado: (2017)

Mammary Development and Breast Cancer: a Notch Perspective
por: Chen, Weizhen, et al.
Publicado: (2021)

Spontaneous Regression of Induced Mammary Tumours in Rats
por: Young, Stretton, et al.
Publicado: (1963)

The Notch system during pubertal development of the bovine mammary gland
por: Bonadeo, Nadia, et al.
Publicado: (2019)

NOTCH and AKT Signalling Interact to Drive Mammary Tumour Heterogeneity
por: Ordonez, Liliana, et al.
Publicado: (2023)

CEACAM1 controls the EMT switch in murine mammary carcinoma in vitro and in vivo
por: Florian, Wegwitz, et al.
Publicado: (2016)

Effects of serum on mammary epithelial proliferation in vitro during mammary gland development
Publicado: (1975)

Hormone Signaling Requirements for the Conversion of Non-Mammary Mouse Cells to Mammary Cell Fate(s) in Vivo
por: Boulanger, Corinne A., et al.
Publicado: (2015)

In vitro cellular immunity in mammary carcinoma.
por: Jones, B. M., et al.
Publicado: (1974)

Neoplastic transformation of porcine mammary epithelial cells in vitro and tumor formation in vivo
por: Rowson-Hodel, A. R., et al.
Publicado: (2015)

Pygopus 2: tilting the Wnt-Notch balance in mammary epithelial lineage determination
por: Roarty, Kevin, et al.
Publicado: (2013)

C-jun Inhibits Mammary Apoptosis In Vivo
por: Katiyar, Sanjay, et al.
Publicado: (2010)

Tumorsphere as an effective in vitro platform for screening anti-cancer stem cell drugs
por: Lee, Che-Hsin, et al.
Publicado: (2015)

The aqueous extract of brucea javanica reduces tumorigenicity of human lung cancer tumorspheres
por: Kim, Seung-Hun, et al.
Publicado: (2021)

Understanding the influence of substrate when growing tumorspheres
por: Benítez, Lucía, et al.
Publicado: (2021)

Expression of prolactin receptors in normal canine mammary tissue, canine mammary adenomas and mammary adenocarcinomas
por: Michel, Erika, et al.
Publicado: (2012)

Establishment of Mammary Gland Model In Vitro: Culture and Evaluation of a Yak Mammary Epithelial Cell Line
por: Fu, Mei, et al.
Publicado: (2014)

Mammary stem cells: angels or demons in mammary gland?
por: Chen, Xueman, et al.
Publicado: (2017)

Mammary epithelial cell phenotype disruption in vitro and in vivo through ERalpha36 overexpression
por: Thiebaut, Charlène, et al.
Publicado: (2017)

Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells
por: Dontu, Gabriela, et al.
Publicado: (2004)

Macrophage content and colony-forming potential in mouse mammary carcinomas.
por: Nash, J. R., et al.
Publicado: (1981)

Mammary Carcinoma
por: Ray, P. N.
Publicado: (1950)

Mammary Abscess
por: Crosby, A. B.
Publicado: (1859)

Mammary Abscess
Publicado: (1875)

Mammary Inflammation
por: Danforth, Willis
Publicado: (1853)

Activating Transcription Factor-5 Knockdown Reduces Aggressiveness of Mammary Tumor Cells and Attenuates Mammary Tumor Growth
por: Ben-Shmuel, Sarit, et al.
Publicado: (2017)

Possibility of in vitro Alterations in Cultures of Mammary Carcinoma Cells, and Altered Immunological Response in the Rat: Acquired Capacity to Reject Injections of Mammary Carcinoma Cells and Implants of Mammary Carcinoma
por: Stone, David, et al.
Publicado: (1972)

TB-8 Genetic and molecular properties of long-term proliferating tumorsphere -forming glioma derived cells
por: Kijima, Noriyuki, et al.
Publicado: (2021)

Human Breast Cancer Cells Are Redirected to Mammary Epithelial Cells upon Interaction with the Regenerating Mammary Gland Microenvironment In-Vivo
por: Bussard, Karen M., et al.
Publicado: (2012)

Characterization of Hyaluronan Localization in the Developing Mammary Gland and Mammary Tumors
por: Witschen, Patrice M., et al.
Publicado: (2023)

Success of tumorsphere isolation from WHO grade IV gliomas does not correlate with the weight of fresh tumor specimens: an immunohistochemical characterization of tumorsphere differentiation
por: Sung, Kyoung Su, et al.
Publicado: (2016)

Mammary gland-specific ablation of focal adhesion kinase reduces the incidence of p53-mediated mammary tumour formation
por: van Miltenburg, M H A M, et al.
Publicado: (2014)

Prepubertal exposure to zearalenone or genistein reduces mammary tumorigenesis
por: Hilakivi-Clarke, L, et al.
Publicado: (1999)

Mammary Tumours in Hybrid Mice: the Presence and Transmission of the Mammary Tumour Agent
por: Foulds, L.
Publicado: (1949)

Bovine mammary epithelial cell cultures for the study of mammary gland functions
por: Jedrzejczak, Magdalena, et al.
Publicado: (2013)

The Effect of Mammary Extracellular Matrix in Controlling Oral and Mammary Cancer Cells
por: Pavuluri, Sivapriya, et al.
Publicado: (2018)

Chemo-immunotherapy induces tumor regression in a mouse model of spontaneous mammary carcinogenesis
por: Aricò, Eleonora, et al.
Publicado: (2016)

Notch3 Knockout Suppresses Mouse Mammary Gland Development and Inhibits the Proliferation of 4T1 Murine Mammary Carcinoma Cells via CCL2/CCR4 Axis
por: Xiong, Wei, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_iodu0dh3hi1crainfi6s91dmon