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Breast vibro-acoustography: initial results show promise

INTRODUCTION: Vibro-acoustography (VA) is a recently developed imaging modality that is sensitive to the dynamic characteristics of tissue. It detects low-frequency harmonic vibrations in tissue that are induced by the radiation force of ultrasound. Here, we have investigated applications of VA for...

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Autores principales: Alizad, Azra, Whaley, Dana H, Urban, Matthew W, Carter, Rickey E, Kinnick, Randall R, Greenleaf, James F, Fatemi, Mostafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053105/
https://www.ncbi.nlm.nih.gov/pubmed/23021305
http://dx.doi.org/10.1186/bcr3323
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author Alizad, Azra
Whaley, Dana H
Urban, Matthew W
Carter, Rickey E
Kinnick, Randall R
Greenleaf, James F
Fatemi, Mostafa
author_facet Alizad, Azra
Whaley, Dana H
Urban, Matthew W
Carter, Rickey E
Kinnick, Randall R
Greenleaf, James F
Fatemi, Mostafa
author_sort Alizad, Azra
collection PubMed
description INTRODUCTION: Vibro-acoustography (VA) is a recently developed imaging modality that is sensitive to the dynamic characteristics of tissue. It detects low-frequency harmonic vibrations in tissue that are induced by the radiation force of ultrasound. Here, we have investigated applications of VA for in vivo breast imaging. METHODS: A recently developed combined mammography-VA system for in vivo breast imaging was tested on female volunteers, aged 25 years or older, with suspected breast lesions on their clinical examination. After mammography, a set of VA scans was acquired by the experimental device. In a masked assessment, VA images were evaluated independently by 3 reviewers who identified mass lesions and calcifications. The diagnostic accuracy of this imaging method was determined by comparing the reviewers' responses with clinical data. RESULTS: We collected images from 57 participants: 7 were used for training and 48 for evaluation of diagnostic accuracy (images from 2 participants were excluded because of unexpected imaging artifacts). In total, 16 malignant and 32 benign lesions were examined. Specificity for diagnostic accuracy was 94% or higher for all 3 reviewers, but sensitivity varied (69% to 100%). All reviewers were able to detect 97% of masses, but sensitivity for detection of calcification was lower (≤ 72% for all reviewers). CONCLUSIONS: VA can be used to detect various breast abnormalities, including calcifications and benign and malignant masses, with relatively high specificity. VA technology may lead to a new clinical tool for breast imaging applications.
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spelling pubmed-40531052014-06-12 Breast vibro-acoustography: initial results show promise Alizad, Azra Whaley, Dana H Urban, Matthew W Carter, Rickey E Kinnick, Randall R Greenleaf, James F Fatemi, Mostafa Breast Cancer Res Research Article INTRODUCTION: Vibro-acoustography (VA) is a recently developed imaging modality that is sensitive to the dynamic characteristics of tissue. It detects low-frequency harmonic vibrations in tissue that are induced by the radiation force of ultrasound. Here, we have investigated applications of VA for in vivo breast imaging. METHODS: A recently developed combined mammography-VA system for in vivo breast imaging was tested on female volunteers, aged 25 years or older, with suspected breast lesions on their clinical examination. After mammography, a set of VA scans was acquired by the experimental device. In a masked assessment, VA images were evaluated independently by 3 reviewers who identified mass lesions and calcifications. The diagnostic accuracy of this imaging method was determined by comparing the reviewers' responses with clinical data. RESULTS: We collected images from 57 participants: 7 were used for training and 48 for evaluation of diagnostic accuracy (images from 2 participants were excluded because of unexpected imaging artifacts). In total, 16 malignant and 32 benign lesions were examined. Specificity for diagnostic accuracy was 94% or higher for all 3 reviewers, but sensitivity varied (69% to 100%). All reviewers were able to detect 97% of masses, but sensitivity for detection of calcification was lower (≤ 72% for all reviewers). CONCLUSIONS: VA can be used to detect various breast abnormalities, including calcifications and benign and malignant masses, with relatively high specificity. VA technology may lead to a new clinical tool for breast imaging applications. BioMed Central 2012 2012-09-29 /pmc/articles/PMC4053105/ /pubmed/23021305 http://dx.doi.org/10.1186/bcr3323 Text en Copyright © 2012 Alizad et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Alizad, Azra
Whaley, Dana H
Urban, Matthew W
Carter, Rickey E
Kinnick, Randall R
Greenleaf, James F
Fatemi, Mostafa
Breast vibro-acoustography: initial results show promise
title Breast vibro-acoustography: initial results show promise
title_full Breast vibro-acoustography: initial results show promise
title_fullStr Breast vibro-acoustography: initial results show promise
title_full_unstemmed Breast vibro-acoustography: initial results show promise
title_short Breast vibro-acoustography: initial results show promise
title_sort breast vibro-acoustography: initial results show promise
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053105/
https://www.ncbi.nlm.nih.gov/pubmed/23021305
http://dx.doi.org/10.1186/bcr3323
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