Low levels of Stat5a protein in breast cancer are associated with tumor progression and unfavorable clinical outcomes

INTRODUCTION: Signal transducer and activator of transcripton-5a (Stat5a) and its close homologue, Stat5b, mediate key physiological effects of prolactin and growth hormone in mammary glands. In breast cancer, loss of nuclear localized and tyrosine phosphorylated Stat5a/b is associated with poor pro...

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Detalles Bibliográficos
Autores principales: Peck, Amy R, Witkiewicz, Agnieszka K, Liu, Chengbao, Klimowicz, Alexander C, Stringer, Ginger A, Pequignot, Edward, Freydin, Boris, Yang, Ning, Ertel, Adam, Tran, Thai H, Girondo, Melanie A, Rosenberg, Anne L, Hooke, Jeffrey A, Kovatich, Albert J, Shriver, Craig D, Rimm, David L, Magliocco, Anthony M, Hyslop, Terry, Rui, Hallgeir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053108/
https://www.ncbi.nlm.nih.gov/pubmed/23036105
http://dx.doi.org/10.1186/bcr3328

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