Triple-negative breast cancer and PTEN (phosphatase and tensin homologue)loss are predictors of BRCA1 germline mutations in women with early-onset and familial breast cancer, but not in women with isolated late-onset breast cancer

INTRODUCTION: Given that breast cancers in germline BRCA1 carriers are predominantly estrogen-negative and triple-negative, it has been suggested that women diagnosed with triple-negative breast cancer (TNBC) younger than 50 years should be offered BRCA1 testing, regardless of family cancer characte...

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Detalles Bibliográficos
Autores principales: Phuah, Sze-Yee, Looi, Lai-Meng, Hassan, Norhashimah, Rhodes, Anthony, Dean, Sarah, Taib, Nur Aishah Mohd, Yip, Cheng-Har, Teo, Soo-Hwang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053128/
https://www.ncbi.nlm.nih.gov/pubmed/23116406
http://dx.doi.org/10.1186/bcr3347

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