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High mammographic density in women of Ashkenazi Jewish descent
INTRODUCTION: Percent mammographic density (PMD) adjusted for age and body mass index is one of the strongest risk factors for breast cancer and is known to be approximately 60% heritable. Here we report a finding of an association between genetic ancestry and adjusted PMD. METHODS: We selected self...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053164/ https://www.ncbi.nlm.nih.gov/pubmed/23668689 http://dx.doi.org/10.1186/bcr3424 |
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author | Caswell, Jennifer L Kerlikowske, Karla Shepherd, John A Cummings, Steven R Hu, Donglei Huntsman, Scott Ziv, Elad |
author_facet | Caswell, Jennifer L Kerlikowske, Karla Shepherd, John A Cummings, Steven R Hu, Donglei Huntsman, Scott Ziv, Elad |
author_sort | Caswell, Jennifer L |
collection | PubMed |
description | INTRODUCTION: Percent mammographic density (PMD) adjusted for age and body mass index is one of the strongest risk factors for breast cancer and is known to be approximately 60% heritable. Here we report a finding of an association between genetic ancestry and adjusted PMD. METHODS: We selected self-identified Caucasian women in the California Pacific Medical Center Research Institute Cohort whose screening mammograms placed them in the top or bottom quintiles of age-adjusted and body mass index-adjusted PMD. Our final dataset included 474 women with the highest adjusted PMD and 469 with the lowest genotyped on the Illumina 1 M platform. Principal component analysis (PCA) and identity-by-descent analyses allowed us to infer the women's genetic ancestry and correlate it with adjusted PMD. RESULTS: Women of Ashkenazi Jewish ancestry, as defined by the first principal component of PCA and identity-by-descent analyses, represented approximately 15% of the sample. Ashkenazi Jewish ancestry, defined by the first principal component of PCA, was associated with higher adjusted PMD (P = 0.004). Using multivariate regression to adjust for epidemiologic factors associated with PMD, including age at parity and use of postmenopausal hormone therapy, did not attenuate the association. CONCLUSIONS: Women of Ashkenazi Jewish ancestry, based on genetic analysis, are more likely to have high age-adjusted and body mass index-adjusted PMD. Ashkenazi Jews may have a unique set of genetic variants or environmental risk factors that increase mammographic density. |
format | Online Article Text |
id | pubmed-4053164 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-40531642014-06-12 High mammographic density in women of Ashkenazi Jewish descent Caswell, Jennifer L Kerlikowske, Karla Shepherd, John A Cummings, Steven R Hu, Donglei Huntsman, Scott Ziv, Elad Breast Cancer Res Research Article INTRODUCTION: Percent mammographic density (PMD) adjusted for age and body mass index is one of the strongest risk factors for breast cancer and is known to be approximately 60% heritable. Here we report a finding of an association between genetic ancestry and adjusted PMD. METHODS: We selected self-identified Caucasian women in the California Pacific Medical Center Research Institute Cohort whose screening mammograms placed them in the top or bottom quintiles of age-adjusted and body mass index-adjusted PMD. Our final dataset included 474 women with the highest adjusted PMD and 469 with the lowest genotyped on the Illumina 1 M platform. Principal component analysis (PCA) and identity-by-descent analyses allowed us to infer the women's genetic ancestry and correlate it with adjusted PMD. RESULTS: Women of Ashkenazi Jewish ancestry, as defined by the first principal component of PCA and identity-by-descent analyses, represented approximately 15% of the sample. Ashkenazi Jewish ancestry, defined by the first principal component of PCA, was associated with higher adjusted PMD (P = 0.004). Using multivariate regression to adjust for epidemiologic factors associated with PMD, including age at parity and use of postmenopausal hormone therapy, did not attenuate the association. CONCLUSIONS: Women of Ashkenazi Jewish ancestry, based on genetic analysis, are more likely to have high age-adjusted and body mass index-adjusted PMD. Ashkenazi Jews may have a unique set of genetic variants or environmental risk factors that increase mammographic density. BioMed Central 2013 2013-05-13 /pmc/articles/PMC4053164/ /pubmed/23668689 http://dx.doi.org/10.1186/bcr3424 Text en Copyright © 2013 Caswell et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Caswell, Jennifer L Kerlikowske, Karla Shepherd, John A Cummings, Steven R Hu, Donglei Huntsman, Scott Ziv, Elad High mammographic density in women of Ashkenazi Jewish descent |
title | High mammographic density in women of Ashkenazi Jewish descent |
title_full | High mammographic density in women of Ashkenazi Jewish descent |
title_fullStr | High mammographic density in women of Ashkenazi Jewish descent |
title_full_unstemmed | High mammographic density in women of Ashkenazi Jewish descent |
title_short | High mammographic density in women of Ashkenazi Jewish descent |
title_sort | high mammographic density in women of ashkenazi jewish descent |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053164/ https://www.ncbi.nlm.nih.gov/pubmed/23668689 http://dx.doi.org/10.1186/bcr3424 |
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