The Roles of Biomarkers of Oxidative Stress and Antioxidant in Alzheimer's Disease: A Systematic Review

Purpose. Oxidative stress plays an important role in the pathogenesis of Alzheimer's disease (AD). This paper aims to examine whether biomarkers of oxidative stress and antioxidants could be useful biomarkers in AD, which might form the bases of future clinical studies. Methods. PubMed, SCOPUS,...

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Autores principales: Chang, Ya-Ting, Chang, Wen-Neng, Tsai, Nai-Wen, Huang, Chih-Cheng, Kung, Chia-Te, Su, Yu-Jih, Lin, Wei-Che, Cheng, Ben-Chung, Su, Chih-Min, Chiang, Yi-Fang, Lu, Cheng-Hsien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053273/
https://www.ncbi.nlm.nih.gov/pubmed/24949424
http://dx.doi.org/10.1155/2014/182303
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author Chang, Ya-Ting
Chang, Wen-Neng
Tsai, Nai-Wen
Huang, Chih-Cheng
Kung, Chia-Te
Su, Yu-Jih
Lin, Wei-Che
Cheng, Ben-Chung
Su, Chih-Min
Chiang, Yi-Fang
Lu, Cheng-Hsien
author_facet Chang, Ya-Ting
Chang, Wen-Neng
Tsai, Nai-Wen
Huang, Chih-Cheng
Kung, Chia-Te
Su, Yu-Jih
Lin, Wei-Che
Cheng, Ben-Chung
Su, Chih-Min
Chiang, Yi-Fang
Lu, Cheng-Hsien
author_sort Chang, Ya-Ting
collection PubMed
description Purpose. Oxidative stress plays an important role in the pathogenesis of Alzheimer's disease (AD). This paper aims to examine whether biomarkers of oxidative stress and antioxidants could be useful biomarkers in AD, which might form the bases of future clinical studies. Methods. PubMed, SCOPUS, and Web of Science were systematically queried to obtain studies with available data regarding markers of oxidative stress and antioxidants from subjects with AD. Results and Conclusion. Although most studies show elevated serum markers of lipid peroxidation in AD, there is no sufficient evidence to justify the routine use of biomarkers as predictors of severity or outcome in AD.
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spelling pubmed-40532732014-06-19 The Roles of Biomarkers of Oxidative Stress and Antioxidant in Alzheimer's Disease: A Systematic Review Chang, Ya-Ting Chang, Wen-Neng Tsai, Nai-Wen Huang, Chih-Cheng Kung, Chia-Te Su, Yu-Jih Lin, Wei-Che Cheng, Ben-Chung Su, Chih-Min Chiang, Yi-Fang Lu, Cheng-Hsien Biomed Res Int Review Article Purpose. Oxidative stress plays an important role in the pathogenesis of Alzheimer's disease (AD). This paper aims to examine whether biomarkers of oxidative stress and antioxidants could be useful biomarkers in AD, which might form the bases of future clinical studies. Methods. PubMed, SCOPUS, and Web of Science were systematically queried to obtain studies with available data regarding markers of oxidative stress and antioxidants from subjects with AD. Results and Conclusion. Although most studies show elevated serum markers of lipid peroxidation in AD, there is no sufficient evidence to justify the routine use of biomarkers as predictors of severity or outcome in AD. Hindawi Publishing Corporation 2014 2014-05-14 /pmc/articles/PMC4053273/ /pubmed/24949424 http://dx.doi.org/10.1155/2014/182303 Text en Copyright © 2014 Ya-Ting Chang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Chang, Ya-Ting
Chang, Wen-Neng
Tsai, Nai-Wen
Huang, Chih-Cheng
Kung, Chia-Te
Su, Yu-Jih
Lin, Wei-Che
Cheng, Ben-Chung
Su, Chih-Min
Chiang, Yi-Fang
Lu, Cheng-Hsien
The Roles of Biomarkers of Oxidative Stress and Antioxidant in Alzheimer's Disease: A Systematic Review
title The Roles of Biomarkers of Oxidative Stress and Antioxidant in Alzheimer's Disease: A Systematic Review
title_full The Roles of Biomarkers of Oxidative Stress and Antioxidant in Alzheimer's Disease: A Systematic Review
title_fullStr The Roles of Biomarkers of Oxidative Stress and Antioxidant in Alzheimer's Disease: A Systematic Review
title_full_unstemmed The Roles of Biomarkers of Oxidative Stress and Antioxidant in Alzheimer's Disease: A Systematic Review
title_short The Roles of Biomarkers of Oxidative Stress and Antioxidant in Alzheimer's Disease: A Systematic Review
title_sort roles of biomarkers of oxidative stress and antioxidant in alzheimer's disease: a systematic review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053273/
https://www.ncbi.nlm.nih.gov/pubmed/24949424
http://dx.doi.org/10.1155/2014/182303
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