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Antimicrobial Activity of Coronarin D and Its Synergistic Potential with Antibiotics

Coronarin D is a labdane-type diterpene from the rhizomes of Hedychium coronarium. In the view of our ongoing effort to explore its novel biological activity, antimicrobial activity study of coronarin D was performed. The results showed that coronarin D was active against tested Gram-positive bacter...

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Autores principales: Reuk-ngam, Nanthawan, Chimnoi, Nitirat, Khunnawutmanotham, Nisachon, Techasakul, Supanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053275/
https://www.ncbi.nlm.nih.gov/pubmed/24949458
http://dx.doi.org/10.1155/2014/581985
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author Reuk-ngam, Nanthawan
Chimnoi, Nitirat
Khunnawutmanotham, Nisachon
Techasakul, Supanna
author_facet Reuk-ngam, Nanthawan
Chimnoi, Nitirat
Khunnawutmanotham, Nisachon
Techasakul, Supanna
author_sort Reuk-ngam, Nanthawan
collection PubMed
description Coronarin D is a labdane-type diterpene from the rhizomes of Hedychium coronarium. In the view of our ongoing effort to explore its novel biological activity, antimicrobial activity study of coronarin D was performed. The results showed that coronarin D was active against tested Gram-positive bacteria, inactive for tested Gram-negative bacteria, and weakly active against tested fungi. The antibacterial effect of the combination of coronarin D with nine classical antibiotics against four Gram-positive bacteria was also evaluated. The fractional inhibitory concentration indices (FIC(I)) of coronarin D-antibiotics combinations, calculated from the checkerboard assay, were used as synergism indicator. Out of 36 combinations, 47% showed total synergism, 33% had partial synergistic interaction, 17% showed no effect, and 3% showed antagonism. By combination with coronarin D at concentration of 0.25 minimal inhibitory concentration (MIC), the activities of antibiotics were boosted to 4- to 128-fold. These finding suggested an attractive approach to combat the infectious diseases by using coronarin D-antibiotic drug combination.
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spelling pubmed-40532752014-06-19 Antimicrobial Activity of Coronarin D and Its Synergistic Potential with Antibiotics Reuk-ngam, Nanthawan Chimnoi, Nitirat Khunnawutmanotham, Nisachon Techasakul, Supanna Biomed Res Int Research Article Coronarin D is a labdane-type diterpene from the rhizomes of Hedychium coronarium. In the view of our ongoing effort to explore its novel biological activity, antimicrobial activity study of coronarin D was performed. The results showed that coronarin D was active against tested Gram-positive bacteria, inactive for tested Gram-negative bacteria, and weakly active against tested fungi. The antibacterial effect of the combination of coronarin D with nine classical antibiotics against four Gram-positive bacteria was also evaluated. The fractional inhibitory concentration indices (FIC(I)) of coronarin D-antibiotics combinations, calculated from the checkerboard assay, were used as synergism indicator. Out of 36 combinations, 47% showed total synergism, 33% had partial synergistic interaction, 17% showed no effect, and 3% showed antagonism. By combination with coronarin D at concentration of 0.25 minimal inhibitory concentration (MIC), the activities of antibiotics were boosted to 4- to 128-fold. These finding suggested an attractive approach to combat the infectious diseases by using coronarin D-antibiotic drug combination. Hindawi Publishing Corporation 2014 2014-05-15 /pmc/articles/PMC4053275/ /pubmed/24949458 http://dx.doi.org/10.1155/2014/581985 Text en Copyright © 2014 Nanthawan Reuk-ngam et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Reuk-ngam, Nanthawan
Chimnoi, Nitirat
Khunnawutmanotham, Nisachon
Techasakul, Supanna
Antimicrobial Activity of Coronarin D and Its Synergistic Potential with Antibiotics
title Antimicrobial Activity of Coronarin D and Its Synergistic Potential with Antibiotics
title_full Antimicrobial Activity of Coronarin D and Its Synergistic Potential with Antibiotics
title_fullStr Antimicrobial Activity of Coronarin D and Its Synergistic Potential with Antibiotics
title_full_unstemmed Antimicrobial Activity of Coronarin D and Its Synergistic Potential with Antibiotics
title_short Antimicrobial Activity of Coronarin D and Its Synergistic Potential with Antibiotics
title_sort antimicrobial activity of coronarin d and its synergistic potential with antibiotics
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053275/
https://www.ncbi.nlm.nih.gov/pubmed/24949458
http://dx.doi.org/10.1155/2014/581985
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