Intra-Myocardial Injection of Both Growth Factors and Heart Derived Sca-1(+)/CD31(−) Cells Attenuates Post-MI LV Remodeling More Than Does Cell Transplantation Alone: Neither Intervention Enhances Functionally Significant Cardiomyocyte Regeneration

Insulin-like growth factor 1 (IGF-1) and hepatocyte growth factor (HGF) are two potent cell survival and regenerative factors in response to myocardial injury (MI). We hypothesized that simultaneous delivery of IGF+HGF combined with Sca-1(+)/CD31(−) cells would improve the outcome of transplantation...

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Detalles Bibliográficos
Autores principales: Wang, Xiaohong, Li, Qinglu, Hu, Qingsong, Suntharalingam, Piradeep, From, Arthur H. L., Zhang, Jianyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053321/
https://www.ncbi.nlm.nih.gov/pubmed/24919180
http://dx.doi.org/10.1371/journal.pone.0095247

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