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Pharmacological Investigations of N-Substituent Variation in Morphine and Oxymorphone: Opioid Receptor Binding, Signaling and Antinociceptive Activity

Morphine and structurally related derivatives are highly effective analgesics, and the mainstay in the medical management of moderate to severe pain. Pharmacological actions of opioid analgesics are primarily mediated through agonism at the µ opioid peptide (MOP) receptor, a G protein-coupled recept...

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Detalles Bibliográficos
Autores principales:	Ben Haddou, Tanila, Béni, Szabolcs, Hosztafi, Sándor, Malfacini, Davide, Calo, Girolamo, Schmidhammer, Helmut, Spetea, Mariana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053365/ https://www.ncbi.nlm.nih.gov/pubmed/24919067 http://dx.doi.org/10.1371/journal.pone.0099231

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