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Loss of HMG-CoA Reductase in C. elegans Causes Defects in Protein Prenylation and Muscle Mitochondria

HMG-CoA reductase is the rate-limiting enzyme in the mevalonate pathway and the target of cholesterol-lowering statins. We characterized the C. elegans hmgr-1(tm4368) mutant, which lacks HMG-CoA reductase, and show that its phenotypes recapitulate that of statin treatment, though in a more severe fo...

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Detalles Bibliográficos
Autores principales:	Ranji, Parmida, Rauthan, Manish, Pitot, Christophe, Pilon, Marc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053411/ https://www.ncbi.nlm.nih.gov/pubmed/24918786 http://dx.doi.org/10.1371/journal.pone.0100033

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