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Prostaglandin E(2) Promotes Features of Replicative Senescence in Chronically Activated Human CD8+ T Cells

Prostaglandin E(2) (PGE(2)), a pleiotropic immunomodulatory molecule, and its free radical catalyzed isoform, iso-PGE(2), are frequently elevated in the context of cancer and chronic infection. Previous studies have documented the effects of PGE(2) on the various CD4+ T cell functions, but little is...

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Detalles Bibliográficos
Autores principales:	Chou, Jennifer P., Ramirez, Christina M., Ryba, Danielle M., Koduri, Megha P., Effros, Rita B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053423/ https://www.ncbi.nlm.nih.gov/pubmed/24918932 http://dx.doi.org/10.1371/journal.pone.0099432

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