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Dose-Dependent Effect of Estrogen Suppresses the Osteo-Adipogenic Transdifferentiation of Osteoblasts via Canonical Wnt Signaling Pathway
Fat infiltration within marrow cavity is one of multitudinous features of estrogen deficiency, which leads to a decline in bone formation functionality. The origin of this fat is unclear, but one possibility is that it is derived from osteoblasts, which transdifferentiate into adipocytes that produc...
Autores principales: | Gao, Bo, Huang, Qiang, Lin, Yan-Shui, Wei, Bo-Yuan, Guo, Yun-Shan, Sun, Zhen, Wang, Long, Fan, Jing, Zhang, Hong-Yang, Han, Yue-Hu, Li, Xiao-Jie, Shi, Jun, Liu, Jian, Yang, Liu, Luo, Zhuo-Jing |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053448/ https://www.ncbi.nlm.nih.gov/pubmed/24918446 http://dx.doi.org/10.1371/journal.pone.0099137 |
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