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Redistribution of H3K27me3 and acetylated histone H4 upon exposure to azacitidine and decitabine results in de-repression of the AML1/ETO target gene IL3

Human acute myeloid leukemia is characterized by a block in maturation caused by genetic and epigenetic alterations. We studied the effects of low concentrations of the DNA methyltransferase (DNMT) inhibitors 5-azacitidine and decitabine on apoptosis and on chromatin remodeling in an AML1/ETO induci...

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Detalles Bibliográficos
Autores principales:	Buchi, Francesca, Masala, Erico, Rossi, Alessia, Valencia, Ana, Spinelli, Elena, Sanna, Alessandro, Gozzini, Antonella, Santini, Valeria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Landes Bioscience 2014
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053457/ https://www.ncbi.nlm.nih.gov/pubmed/24300456 http://dx.doi.org/10.4161/epi.27322

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