RevSex duplication-induced and sex-related differences in the SOX9 regulatory region chromatin landscape in human fibroblasts

It was recently shown that duplications of the RevSex element, located 0.5 Mb upstream of SOX9, cause XX-disorder of sex development (DSD), and that deletions cause XY-DSD. To explore how a 148 kb RevSex duplication could have turned on gonadal SOX9 expression in the absence of SRY in an XX-male, we...

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Detalles Bibliográficos
Autores principales: Lybæk, Helle, de Bruijn, Diederik, den Engelsman-van Dijk, Anke HA, Vanichkina, Darya, Nepal, Chirag, Brendehaug, Atle, Houge, Gunnar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053460/
https://www.ncbi.nlm.nih.gov/pubmed/24351654
http://dx.doi.org/10.4161/epi.27474

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