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voom: precision weights unlock linear model analysis tools for RNA-seq read counts

New normal linear modeling strategies are presented for analyzing read counts from RNA-seq experiments. The voom method estimates the mean-variance relationship of the log-counts, generates a precision weight for each observation and enters these into the limma empirical Bayes analysis pipeline. Thi...

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Detalles Bibliográficos
Autores principales:	Law, Charity W, Chen, Yunshun, Shi, Wei, Smyth, Gordon K
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Method
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053721/ https://www.ncbi.nlm.nih.gov/pubmed/24485249 http://dx.doi.org/10.1186/gb-2014-15-2-r29

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