Getting a Grip on piRNA Cluster Transcription

The generation of piRNAs from long primary transcripts requires specialized factors that distinguish these precursors from canonical RNA polymerase II transcripts. Mohn et al. and Zhang et al. provide evidence that in Drosophila melanogaster noncanonical transcription coupled with splicing inhibitio...

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Detalles Bibliográficos
Autores principales: Sapetschnig, Alexandra, Miska, Eric A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2014
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053829/
https://www.ncbi.nlm.nih.gov/pubmed/24906143
http://dx.doi.org/10.1016/j.cell.2014.05.022
Descripción
Sumario:The generation of piRNAs from long primary transcripts requires specialized factors that distinguish these precursors from canonical RNA polymerase II transcripts. Mohn et al. and Zhang et al. provide evidence that in Drosophila melanogaster noncanonical transcription coupled with splicing inhibition differentiates piRNA precursors from mRNAs and ensures their correct processing.

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