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Genome-wide analysis identifies a functional association of Tet1 and Polycomb repressive complex 2 in mouse embryonic stem cells

BACKGROUND: Ten-Eleven Translocation (TETs)proteins mediate the oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). Tet1 is expressed at high levels in mouse embryonic stem cells (ESCs), where it mediates the induction of 5hmC decoration on gene-regulatory elements. While the func...

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Detalles Bibliográficos
Autores principales:	Neri, Francesco, Incarnato, Danny, Krepelova, Anna, Rapelli, Stefania, Pagnani, Andrea, Zecchina, Riccardo, Parlato, Caterina, Oliviero, Salvatore
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053938/ https://www.ncbi.nlm.nih.gov/pubmed/23987249 http://dx.doi.org/10.1186/gb-2013-14-8-r91

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