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Use of corticosteroids during pregnancy and risk of asthma in offspring: a nationwide Danish cohort study
OBJECTIVE: To examine whether in utero exposure to local and systemic corticosteroids is associated with asthma development in offspring. DESIGN: Cohort study. SETTING: Denmark. PARTICIPANTS: We included all singletons born alive in Denmark between 1996 and 2009. Data on maternal corticosteroid use,...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054622/ https://www.ncbi.nlm.nih.gov/pubmed/24902733 http://dx.doi.org/10.1136/bmjopen-2014-005053 |
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author | Byrjalsen, Anna Frøslev, Trine Telén Andersen, Ane Birgitte Olsen, Morten Toft Sørensen, Henrik |
author_facet | Byrjalsen, Anna Frøslev, Trine Telén Andersen, Ane Birgitte Olsen, Morten Toft Sørensen, Henrik |
author_sort | Byrjalsen, Anna |
collection | PubMed |
description | OBJECTIVE: To examine whether in utero exposure to local and systemic corticosteroids is associated with asthma development in offspring. DESIGN: Cohort study. SETTING: Denmark. PARTICIPANTS: We included all singletons born alive in Denmark between 1996 and 2009. Data on maternal corticosteroid use, asthma in offspring and covariates were obtained from medical registries. MAIN OUTCOME MEASURES: We compared asthma risks of children prenatally exposed to corticosteroids and of children of former corticosteroid users with that of unexposed children. We computed absolute risks and used proportional-hazards regression to compute adjusted HRs (aHRs). Using logistic regression we compared exposed children with unexposed siblings in a ‘within-mother-between-pregnancy’ analysis. Adjustment addressed varying length of follow-up. RESULTS: We identified 877 778 children, 3.6% of whom were prenatally exposed to systemic (n=5327) or local (n=24 436) corticosteroids. A total of 105 677 children developed asthma during follow-up with a 10-year risk of 18.4% among the exposed and 13.5% among the unexposed. The aHR was 1.54 (95% CI 1.45 to 1.65) for systemic use, 1.45 (95% CI 1.40 to 1.50) for local use and 1.32 (95% CI 1.30 to 1.34) for former use. The adjusted OR of the ‘within-mother-between-pregnancy’ analysis was 1.11 (95% CI 0.98 to 1.25). CONCLUSIONS: These population-based data do not support a strong causal association between maternal corticosteroid use during pregnancy and increased asthma risk in offspring. |
format | Online Article Text |
id | pubmed-4054622 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-40546222014-06-13 Use of corticosteroids during pregnancy and risk of asthma in offspring: a nationwide Danish cohort study Byrjalsen, Anna Frøslev, Trine Telén Andersen, Ane Birgitte Olsen, Morten Toft Sørensen, Henrik BMJ Open Epidemiology OBJECTIVE: To examine whether in utero exposure to local and systemic corticosteroids is associated with asthma development in offspring. DESIGN: Cohort study. SETTING: Denmark. PARTICIPANTS: We included all singletons born alive in Denmark between 1996 and 2009. Data on maternal corticosteroid use, asthma in offspring and covariates were obtained from medical registries. MAIN OUTCOME MEASURES: We compared asthma risks of children prenatally exposed to corticosteroids and of children of former corticosteroid users with that of unexposed children. We computed absolute risks and used proportional-hazards regression to compute adjusted HRs (aHRs). Using logistic regression we compared exposed children with unexposed siblings in a ‘within-mother-between-pregnancy’ analysis. Adjustment addressed varying length of follow-up. RESULTS: We identified 877 778 children, 3.6% of whom were prenatally exposed to systemic (n=5327) or local (n=24 436) corticosteroids. A total of 105 677 children developed asthma during follow-up with a 10-year risk of 18.4% among the exposed and 13.5% among the unexposed. The aHR was 1.54 (95% CI 1.45 to 1.65) for systemic use, 1.45 (95% CI 1.40 to 1.50) for local use and 1.32 (95% CI 1.30 to 1.34) for former use. The adjusted OR of the ‘within-mother-between-pregnancy’ analysis was 1.11 (95% CI 0.98 to 1.25). CONCLUSIONS: These population-based data do not support a strong causal association between maternal corticosteroid use during pregnancy and increased asthma risk in offspring. BMJ Publishing Group 2014-06-05 /pmc/articles/PMC4054622/ /pubmed/24902733 http://dx.doi.org/10.1136/bmjopen-2014-005053 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Epidemiology Byrjalsen, Anna Frøslev, Trine Telén Andersen, Ane Birgitte Olsen, Morten Toft Sørensen, Henrik Use of corticosteroids during pregnancy and risk of asthma in offspring: a nationwide Danish cohort study |
title | Use of corticosteroids during pregnancy and risk of asthma in offspring: a nationwide Danish cohort study |
title_full | Use of corticosteroids during pregnancy and risk of asthma in offspring: a nationwide Danish cohort study |
title_fullStr | Use of corticosteroids during pregnancy and risk of asthma in offspring: a nationwide Danish cohort study |
title_full_unstemmed | Use of corticosteroids during pregnancy and risk of asthma in offspring: a nationwide Danish cohort study |
title_short | Use of corticosteroids during pregnancy and risk of asthma in offspring: a nationwide Danish cohort study |
title_sort | use of corticosteroids during pregnancy and risk of asthma in offspring: a nationwide danish cohort study |
topic | Epidemiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054622/ https://www.ncbi.nlm.nih.gov/pubmed/24902733 http://dx.doi.org/10.1136/bmjopen-2014-005053 |
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