Cargando…

Rationale and study design of the Adaptive study of IL-2 dose on regulatory T cells in type 1 diabetes (DILT1D): a non-randomised, open label, adaptive dose finding trial

INTRODUCTION: CD4 T regulatory cells (Tregs) are crucial for the maintenance of self-tolerance and are deficient in many common autoimmune diseases such as type 1 diabetes (T1D). Interleukin 2 (IL-2) plays a major role in the activation and function of Tregs and treatment with ultra-low dose (ULD) I...

Descripción completa

Detalles Bibliográficos
Autores principales:	Waldron-Lynch, Frank, Kareclas, Paula, Irons, Kathryn, Walker, Neil M, Mander, Adrian, Wicker, Linda S, Todd, John A, Bond, Simon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2014
Materias:	Diabetes and Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054640/ https://www.ncbi.nlm.nih.gov/pubmed/24898091 http://dx.doi.org/10.1136/bmjopen-2014-005559

Ejemplares similares

Protocol of the adaptive study of IL-2 dose frequency on regulatory T cells in type 1 diabetes (DILfrequency): a mechanistic, non-randomised, repeat dose, open-label, response-adaptive study
por: Truman, Lucy A, et al.
Publicado: (2015)

Adaptive dose-finding designs to identify multiple doses that achieve multiple response targets
por: Bond, Simon, et al.
Publicado: (2013)

Simulation work in adaptive dose-finding designs to identify dose-intervals that achieve targets in multiple endpoints
por: Howlett, James, et al.
Publicado: (2015)

Effective recruitment of participants to a phase I study using the internet and publicity releases through charities and patient organisations: analysis of the adaptive study of IL-2 dose on regulatory T cells in type 1 diabetes (DILT1D)
por: Heywood, James, et al.
Publicado: (2015)

Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial
por: Todd, John A., et al.
Publicado: (2016)

Randomised controlled trial of Advanced Hybrid Closed Loop in an Adult Population with Type 1 Diabetes (ADAPT): study protocol and rationale
por: de Portu, Simona, et al.
Publicado: (2022)

Study protocol: Minimum effective low dose: anti-human thymocyte globulin (MELD-ATG): phase II, dose ranging, efficacy study of antithymocyte globulin (ATG) within 6 weeks of diagnosis of type 1 diabetes
por: Wilhelm-Benartzi, Charlotte S, et al.
Publicado: (2021)

The Rationale for Continuous Glucose Monitoring-based Diabetes Treatment Decisions and Non-adjunctive Continuous Glucose Monitoring Use
por: Price, David, et al.
Publicado: (2016)

Rationale and design of Short-Term EXenatide therapy in Acute ischaemic Stroke (STEXAS): a randomised, open-label, parallel-group study
por: McGrath, Rachel T, et al.
Publicado: (2016)

Rationale and design of the CORE (COrticosteroids REvised) study: protocol
por: Stam, Suzanne P, et al.
Publicado: (2022)

Low-dose IL-2 reduces IL-21(+) T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes
por: Zhang, Jia-Yuan, et al.
Publicado: (2022)

An open-label, flexible dose adaptive study evaluating the efficacy of vortioxetine in subjects with panic disorder
por: Shah, Anish, et al.
Publicado: (2018)

Low-dose IL-2 enhances the generation of IL-10-producing immunoregulatory B cells
por: Inaba, Akimichi, et al.
Publicado: (2023)

Rationale and protocol for the After Diabetes Diagnosis REsearch Support System (ADDRESS): an incident and high risk type 1 diabetes UK cohort study
por: Walkey, Helen C, et al.
Publicado: (2017)

The German Gestational Diabetes Study (PREG), a prospective multicentre cohort study: rationale, methodology and design
por: Fritsche, Louise, et al.
Publicado: (2022)

A phase‐1, open‐label, single‐dose study of the pharmacokinetics of buparlisib in subjects with mild to severe hepatic impairment
por: Csonka, Denes, et al.
Publicado: (2016)

A co-design study to develop supportive interventions to improve psychological and social adaptation among adults with new-onset type 1 diabetes in Denmark and the UK
por: Due-Christensen, Mette, et al.
Publicado: (2021)

Model selection and sample size adaptation: HYPAZ trial
por: Bond, Simon, et al.
Publicado: (2011)

Adaptive dose painting for prostate cancer
por: Fredén, Emil, et al.
Publicado: (2022)

Study of peripheral dose from low-dose CT to adaptive radiotherapy of postoperative prostate cancer
por: Gan, Guanghui, et al.
Publicado: (2023)

Rationale and cross-sectional study design of the Research on Obesity and type 2 Diabetes among African Migrants: the RODAM study
por: Agyemang, Charles, et al.
Publicado: (2014)

Prism adaptation and spatial neglect: the need for dose-finding studies
por: Goedert, Kelly M., et al.
Publicado: (2015)

Medication following bariatric surgery for type 2 diabetes mellitus (BY-PLUS) study: rationale and design of a randomised controlled study
por: Sudlow, Alexis, et al.
Publicado: (2022)

Building an adaptive dose simulation framework to aid dose and schedule selection
por: Hooijmaijers, Richard, et al.
Publicado: (2023)

Cultural adaptation of a patient decision-aid for insulin therapy
por: Tan, Ngiap Chuan, et al.
Publicado: (2020)

Pregnancies in Diabetes and Obesity: The Capacity-Load Model of Placental Adaptation
por: Desoye, Gernot, et al.
Publicado: (2021)

Renal Effects of High-Dose Versus Low-Dose Lisinopril in Patients With Diabetic Nephropathy
por: Rashid, Farah R, et al.
Publicado: (2022)

MON-LB113 Insulin Resistance in Type 1 Diabetes Managed With Metformin (INTIMET): Rationale and Study Design of a Randomised Placebo-Controlled Trial
por: Snaith, Jennifer R, et al.
Publicado: (2020)

Efficacy and Safety of a Fixed-Dose Combination of Vildagliptin and Pioglitazone in Indian Patients With Type 2 Diabetes Mellitus: A Randomized, Open-Label, Comparative, Phase III Study
por: Erande, Suhas, et al.
Publicado: (2023)

An Open Label, Adaptive, Phase 1 Trial of High‐Dose Oral Nitazoxanide in Healthy Volunteers: An Antiviral Candidate for SARS‐CoV‐2
por: Walker, Lauren E., et al.
Publicado: (2021)

Rationale and design of a cross-sectional study to investigate and describe the chronotype of patients with type 2 diabetes and the effect on glycaemic control: the CODEC study
por: Brady, Emer M, et al.
Publicado: (2019)

Rationale and design of Diabetes Prevention with active Vitamin D (DPVD): a randomised, double-blind, placebo-controlled study
por: Kawahara, Tetsuya, et al.
Publicado: (2016)

The Perils of Adapting to Dose Errors in Radiation Therapy
por: Mišić, Velibor V., et al.
Publicado: (2015)

Opioid dose regimen shapes mesolimbic adaptations
por: Cahill, Catherine M.
Publicado: (2020)

Cure Rates After a Single Dose of Radioactive Iodine to Treat Hyperthyroidism: The Fixed-Dose Regimen
por: Madu, Nneka M, et al.
Publicado: (2022)

Adaptive dosing of anticancer drugs in neonates: facilitating evidence-based dosing regimens
por: Veal, Gareth J., et al.
Publicado: (2016)

Pilot Study on Image Quality and Radiation Dose of CT Colonography with Adaptive Iterative Dose Reduction Three-Dimensional
por: Shen, Hesong, et al.
Publicado: (2015)

Adaptions to the National Diabetes Prevention Programme lifestyle change curriculum by Hawai‘i Federally Qualified Health Centers: a qualitative descriptive study
por: Stupplebeen, David, et al.
Publicado: (2020)

A prospective, phase II, single-centre, cross-sectional, randomised study investigating Dehydroepiandrosterone supplementation and its Profile in Trauma: ADaPT
por: Bentley, Conor, et al.
Publicado: (2021)

SUN-166 Insulin Dose Calculator in a Pediatric Hospital
por: Shaaban, Sarah, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_btvei6t6fuo9ci64v9dj76j6ka