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Successful Treatment of Mild Pediatric Kasabach-Merritt Phenomenon with Propranolol Monotherapy

Kasabach-Merritt phenomenon (KMP) is relatively rare in childhood and adolescents with high mortality rate because of its hemorrhagic complications and unresponsiveness to treatments such as corticosteroids, vincristine, intravascular embolization, and/or surgery. Propranolol, a β-adrenergic recepto...

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Autores principales: Choeyprasert, Worawut, Natesirinilkul, Rungrote, Charoenkwan, Pimlak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054805/
https://www.ncbi.nlm.nih.gov/pubmed/24963423
http://dx.doi.org/10.1155/2014/364693
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author Choeyprasert, Worawut
Natesirinilkul, Rungrote
Charoenkwan, Pimlak
author_facet Choeyprasert, Worawut
Natesirinilkul, Rungrote
Charoenkwan, Pimlak
author_sort Choeyprasert, Worawut
collection PubMed
description Kasabach-Merritt phenomenon (KMP) is relatively rare in childhood and adolescents with high mortality rate because of its hemorrhagic complications and unresponsiveness to treatments such as corticosteroids, vincristine, intravascular embolization, and/or surgery. Propranolol, a β-adrenergic receptor blocker, has a promising efficacy against vascular tumors such as infantile hemangiomas. But limited and variable data has been reported regarding the role of propranolol in treatment of KMP. We herein reported the successful treatment of mild pediatric KMP with propranolol monotherapy in a case of a five-week-old child with kaposiform hemangioendothelioma with successful treatment of both clinical and hematologic responses. After eight months of follow-up, patient still had stable cutaneous lesion while receiving propranolol monotherapy. Regular hematologic monitoring was done in order to detect any late relapse of the disease. Six months after discontinuation of propranolol, patient has still remained free of hematologic relapse, and primary cutaneous lesion has become a pale pink, 1 cm sized skin lesion.
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spelling pubmed-40548052014-06-24 Successful Treatment of Mild Pediatric Kasabach-Merritt Phenomenon with Propranolol Monotherapy Choeyprasert, Worawut Natesirinilkul, Rungrote Charoenkwan, Pimlak Case Rep Hematol Case Report Kasabach-Merritt phenomenon (KMP) is relatively rare in childhood and adolescents with high mortality rate because of its hemorrhagic complications and unresponsiveness to treatments such as corticosteroids, vincristine, intravascular embolization, and/or surgery. Propranolol, a β-adrenergic receptor blocker, has a promising efficacy against vascular tumors such as infantile hemangiomas. But limited and variable data has been reported regarding the role of propranolol in treatment of KMP. We herein reported the successful treatment of mild pediatric KMP with propranolol monotherapy in a case of a five-week-old child with kaposiform hemangioendothelioma with successful treatment of both clinical and hematologic responses. After eight months of follow-up, patient still had stable cutaneous lesion while receiving propranolol monotherapy. Regular hematologic monitoring was done in order to detect any late relapse of the disease. Six months after discontinuation of propranolol, patient has still remained free of hematologic relapse, and primary cutaneous lesion has become a pale pink, 1 cm sized skin lesion. Hindawi Publishing Corporation 2014 2014-05-22 /pmc/articles/PMC4054805/ /pubmed/24963423 http://dx.doi.org/10.1155/2014/364693 Text en Copyright © 2014 Worawut Choeyprasert et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Choeyprasert, Worawut
Natesirinilkul, Rungrote
Charoenkwan, Pimlak
Successful Treatment of Mild Pediatric Kasabach-Merritt Phenomenon with Propranolol Monotherapy
title Successful Treatment of Mild Pediatric Kasabach-Merritt Phenomenon with Propranolol Monotherapy
title_full Successful Treatment of Mild Pediatric Kasabach-Merritt Phenomenon with Propranolol Monotherapy
title_fullStr Successful Treatment of Mild Pediatric Kasabach-Merritt Phenomenon with Propranolol Monotherapy
title_full_unstemmed Successful Treatment of Mild Pediatric Kasabach-Merritt Phenomenon with Propranolol Monotherapy
title_short Successful Treatment of Mild Pediatric Kasabach-Merritt Phenomenon with Propranolol Monotherapy
title_sort successful treatment of mild pediatric kasabach-merritt phenomenon with propranolol monotherapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054805/
https://www.ncbi.nlm.nih.gov/pubmed/24963423
http://dx.doi.org/10.1155/2014/364693
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