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A simple strategy for heritable chromosomal deletions in zebrafish via the combinatorial action of targeting nucleases
Precise and effective genome-editing tools are essential for functional genomics and gene therapy. Targeting nucleases have been successfully used to edit genomes. However, whole-locus or element-specific deletions abolishing transcript expression have not previously been reported. Here, we show her...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054832/ https://www.ncbi.nlm.nih.gov/pubmed/23815890 http://dx.doi.org/10.1186/gb-2013-14-7-r69 |