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Attenuation of Collagen-Induced Arthritis in Mice by Salmon Proteoglycan

Rheumatoid arthritis (RA) is a serious autoimmune disease caused by chronic inflammation of connective tissues. The basic principle of RA treatment is aimed to reduce joint inflammation. Our previous studies demonstrated that salmon cartilage proteoglycan (PG) suppresses excess inflammation in diffe...

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Autores principales: Yoshimura, Sayuri, Asano, Krisana, Nakane, Akio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054874/
https://www.ncbi.nlm.nih.gov/pubmed/25032213
http://dx.doi.org/10.1155/2014/406453
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author Yoshimura, Sayuri
Asano, Krisana
Nakane, Akio
author_facet Yoshimura, Sayuri
Asano, Krisana
Nakane, Akio
author_sort Yoshimura, Sayuri
collection PubMed
description Rheumatoid arthritis (RA) is a serious autoimmune disease caused by chronic inflammation of connective tissues. The basic principle of RA treatment is aimed to reduce joint inflammation. Our previous studies demonstrated that salmon cartilage proteoglycan (PG) suppresses excess inflammation in different mouse inflammatory diseases. In this study, we investigated the prophylactic effect of PG on the progression of RA using an experimental mouse model, collagen-induced arthritis (CIA). Clinical and histological severity of CIA was attenuated by daily oral administration of PG. In the joints of PG-administered mice, infiltration of macrophages and neutrophils and also osteoclast accumulation were limited. In comparison to nonadministered mice, anti-collagen antibodies in the sera of PG-administered mice did not alter. On the other hand, local expression of interleukin-17A (IL-17A), IL-6, IL-1β, interferon-γ (IFN-γ), C-C chemokine ligand 2 (CCL2), C-X-C chemokine ligand 1 (CXCL1), and CXCL2 in the joints of PG-administered mice decreased. Moreover, in the response of type II collagen- (CII-) restimulation ex vivo, IL-17A and IFN-γ production by splenocytes from PG-administered mice was less than that of control mice. These data suggested that daily ingested PG attenuated CIA pathogenesis by modulating immune response of splenocytes to CII stimulation and local production inflammatory cytokines and chemokines in the joints.
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spelling pubmed-40548742014-07-16 Attenuation of Collagen-Induced Arthritis in Mice by Salmon Proteoglycan Yoshimura, Sayuri Asano, Krisana Nakane, Akio Biomed Res Int Research Article Rheumatoid arthritis (RA) is a serious autoimmune disease caused by chronic inflammation of connective tissues. The basic principle of RA treatment is aimed to reduce joint inflammation. Our previous studies demonstrated that salmon cartilage proteoglycan (PG) suppresses excess inflammation in different mouse inflammatory diseases. In this study, we investigated the prophylactic effect of PG on the progression of RA using an experimental mouse model, collagen-induced arthritis (CIA). Clinical and histological severity of CIA was attenuated by daily oral administration of PG. In the joints of PG-administered mice, infiltration of macrophages and neutrophils and also osteoclast accumulation were limited. In comparison to nonadministered mice, anti-collagen antibodies in the sera of PG-administered mice did not alter. On the other hand, local expression of interleukin-17A (IL-17A), IL-6, IL-1β, interferon-γ (IFN-γ), C-C chemokine ligand 2 (CCL2), C-X-C chemokine ligand 1 (CXCL1), and CXCL2 in the joints of PG-administered mice decreased. Moreover, in the response of type II collagen- (CII-) restimulation ex vivo, IL-17A and IFN-γ production by splenocytes from PG-administered mice was less than that of control mice. These data suggested that daily ingested PG attenuated CIA pathogenesis by modulating immune response of splenocytes to CII stimulation and local production inflammatory cytokines and chemokines in the joints. Hindawi Publishing Corporation 2014 2014-05-22 /pmc/articles/PMC4054874/ /pubmed/25032213 http://dx.doi.org/10.1155/2014/406453 Text en Copyright © 2014 Sayuri Yoshimura et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yoshimura, Sayuri
Asano, Krisana
Nakane, Akio
Attenuation of Collagen-Induced Arthritis in Mice by Salmon Proteoglycan
title Attenuation of Collagen-Induced Arthritis in Mice by Salmon Proteoglycan
title_full Attenuation of Collagen-Induced Arthritis in Mice by Salmon Proteoglycan
title_fullStr Attenuation of Collagen-Induced Arthritis in Mice by Salmon Proteoglycan
title_full_unstemmed Attenuation of Collagen-Induced Arthritis in Mice by Salmon Proteoglycan
title_short Attenuation of Collagen-Induced Arthritis in Mice by Salmon Proteoglycan
title_sort attenuation of collagen-induced arthritis in mice by salmon proteoglycan
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054874/
https://www.ncbi.nlm.nih.gov/pubmed/25032213
http://dx.doi.org/10.1155/2014/406453
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