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Attenuation of Collagen-Induced Arthritis in Mice by Salmon Proteoglycan
Rheumatoid arthritis (RA) is a serious autoimmune disease caused by chronic inflammation of connective tissues. The basic principle of RA treatment is aimed to reduce joint inflammation. Our previous studies demonstrated that salmon cartilage proteoglycan (PG) suppresses excess inflammation in diffe...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054874/ https://www.ncbi.nlm.nih.gov/pubmed/25032213 http://dx.doi.org/10.1155/2014/406453 |
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author | Yoshimura, Sayuri Asano, Krisana Nakane, Akio |
author_facet | Yoshimura, Sayuri Asano, Krisana Nakane, Akio |
author_sort | Yoshimura, Sayuri |
collection | PubMed |
description | Rheumatoid arthritis (RA) is a serious autoimmune disease caused by chronic inflammation of connective tissues. The basic principle of RA treatment is aimed to reduce joint inflammation. Our previous studies demonstrated that salmon cartilage proteoglycan (PG) suppresses excess inflammation in different mouse inflammatory diseases. In this study, we investigated the prophylactic effect of PG on the progression of RA using an experimental mouse model, collagen-induced arthritis (CIA). Clinical and histological severity of CIA was attenuated by daily oral administration of PG. In the joints of PG-administered mice, infiltration of macrophages and neutrophils and also osteoclast accumulation were limited. In comparison to nonadministered mice, anti-collagen antibodies in the sera of PG-administered mice did not alter. On the other hand, local expression of interleukin-17A (IL-17A), IL-6, IL-1β, interferon-γ (IFN-γ), C-C chemokine ligand 2 (CCL2), C-X-C chemokine ligand 1 (CXCL1), and CXCL2 in the joints of PG-administered mice decreased. Moreover, in the response of type II collagen- (CII-) restimulation ex vivo, IL-17A and IFN-γ production by splenocytes from PG-administered mice was less than that of control mice. These data suggested that daily ingested PG attenuated CIA pathogenesis by modulating immune response of splenocytes to CII stimulation and local production inflammatory cytokines and chemokines in the joints. |
format | Online Article Text |
id | pubmed-4054874 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40548742014-07-16 Attenuation of Collagen-Induced Arthritis in Mice by Salmon Proteoglycan Yoshimura, Sayuri Asano, Krisana Nakane, Akio Biomed Res Int Research Article Rheumatoid arthritis (RA) is a serious autoimmune disease caused by chronic inflammation of connective tissues. The basic principle of RA treatment is aimed to reduce joint inflammation. Our previous studies demonstrated that salmon cartilage proteoglycan (PG) suppresses excess inflammation in different mouse inflammatory diseases. In this study, we investigated the prophylactic effect of PG on the progression of RA using an experimental mouse model, collagen-induced arthritis (CIA). Clinical and histological severity of CIA was attenuated by daily oral administration of PG. In the joints of PG-administered mice, infiltration of macrophages and neutrophils and also osteoclast accumulation were limited. In comparison to nonadministered mice, anti-collagen antibodies in the sera of PG-administered mice did not alter. On the other hand, local expression of interleukin-17A (IL-17A), IL-6, IL-1β, interferon-γ (IFN-γ), C-C chemokine ligand 2 (CCL2), C-X-C chemokine ligand 1 (CXCL1), and CXCL2 in the joints of PG-administered mice decreased. Moreover, in the response of type II collagen- (CII-) restimulation ex vivo, IL-17A and IFN-γ production by splenocytes from PG-administered mice was less than that of control mice. These data suggested that daily ingested PG attenuated CIA pathogenesis by modulating immune response of splenocytes to CII stimulation and local production inflammatory cytokines and chemokines in the joints. Hindawi Publishing Corporation 2014 2014-05-22 /pmc/articles/PMC4054874/ /pubmed/25032213 http://dx.doi.org/10.1155/2014/406453 Text en Copyright © 2014 Sayuri Yoshimura et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Yoshimura, Sayuri Asano, Krisana Nakane, Akio Attenuation of Collagen-Induced Arthritis in Mice by Salmon Proteoglycan |
title | Attenuation of Collagen-Induced Arthritis in Mice by Salmon Proteoglycan |
title_full | Attenuation of Collagen-Induced Arthritis in Mice by Salmon Proteoglycan |
title_fullStr | Attenuation of Collagen-Induced Arthritis in Mice by Salmon Proteoglycan |
title_full_unstemmed | Attenuation of Collagen-Induced Arthritis in Mice by Salmon Proteoglycan |
title_short | Attenuation of Collagen-Induced Arthritis in Mice by Salmon Proteoglycan |
title_sort | attenuation of collagen-induced arthritis in mice by salmon proteoglycan |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054874/ https://www.ncbi.nlm.nih.gov/pubmed/25032213 http://dx.doi.org/10.1155/2014/406453 |
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