Knockdown of AKT3 (PKB γ) and PI3KCA Suppresses Cell Viability and Proliferation and Induces the Apoptosis of Glioblastoma Multiforme T98G Cells

Glioblastoma multiforme (GBM) is the most malignant and invasive human brain tumor that is difficult to treat and has a very poor prognosis. Thus, new therapeutic strategies that target GBM are urgently needed. The PI3K/AKT/PTEN signaling pathway is frequently deregulated in a wide range of cancers....

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Detalles Bibliográficos
Autores principales: Paul-Samojedny, Monika, Suchanek, Renata, Borkowska, Paulina, Pudełko, Adam, Owczarek, Aleksander, Kowalczyk, Małgorzata, Machnik, Grzegorz, Fila-Daniłow, Anna, Kowalski, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054922/
https://www.ncbi.nlm.nih.gov/pubmed/24967401
http://dx.doi.org/10.1155/2014/768181

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