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Distinct neural signatures of cognitive subtypes of dyslexia with and without phonological deficits()

Developmental dyslexia can be distinguished as different cognitive subtypes with and without phonological deficits. However, despite some general agreement on the neurobiological basis of dyslexia, the neurofunctional mechanisms underlying these cognitive subtypes remain to be identified. The presen...

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Autores principales: van Ermingen-Marbach, Muna, Grande, Marion, Pape-Neumann, Julia, Sass, Katharina, Heim, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054964/
https://www.ncbi.nlm.nih.gov/pubmed/24936406
http://dx.doi.org/10.1016/j.nicl.2013.03.010
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author van Ermingen-Marbach, Muna
Grande, Marion
Pape-Neumann, Julia
Sass, Katharina
Heim, Stefan
author_facet van Ermingen-Marbach, Muna
Grande, Marion
Pape-Neumann, Julia
Sass, Katharina
Heim, Stefan
author_sort van Ermingen-Marbach, Muna
collection PubMed
description Developmental dyslexia can be distinguished as different cognitive subtypes with and without phonological deficits. However, despite some general agreement on the neurobiological basis of dyslexia, the neurofunctional mechanisms underlying these cognitive subtypes remain to be identified. The present BOLD fMRI study thus aimed at investigating by which distinct and/or shared neural activation patterns dyslexia subtypes are characterized. German dyslexic fourth graders with and without deficits in phonological awareness and age-matched normal readers performed a phonological decision task: does the auditory word contain the phoneme/a/? Both dyslexic subtypes showed increased activation in the right cerebellum (Lobule IV) compared to controls. Subtype-specific increased activation was systematically found for the phonological dyslexics as compared to those without this deficit and controls in the left inferior frontal gyrus (area 44: phonological segmentation), the left SMA (area 6), the left precentral gyrus (area 6) and the right insula. Non-phonological dyslexics revealed subtype-specific increased activation in the left supramarginal gyrus (area PFcm; phonological storage) and angular gyrus (area PGp). The study thus provides the first direct evidence for the neurobiological grounding of dyslexia subtypes. Moreover, the data contribute to a better understanding of the frequently encountered heterogeneous neuroimaging results in the field of dyslexia.
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spelling pubmed-40549642014-06-16 Distinct neural signatures of cognitive subtypes of dyslexia with and without phonological deficits() van Ermingen-Marbach, Muna Grande, Marion Pape-Neumann, Julia Sass, Katharina Heim, Stefan Neuroimage Clin Article Developmental dyslexia can be distinguished as different cognitive subtypes with and without phonological deficits. However, despite some general agreement on the neurobiological basis of dyslexia, the neurofunctional mechanisms underlying these cognitive subtypes remain to be identified. The present BOLD fMRI study thus aimed at investigating by which distinct and/or shared neural activation patterns dyslexia subtypes are characterized. German dyslexic fourth graders with and without deficits in phonological awareness and age-matched normal readers performed a phonological decision task: does the auditory word contain the phoneme/a/? Both dyslexic subtypes showed increased activation in the right cerebellum (Lobule IV) compared to controls. Subtype-specific increased activation was systematically found for the phonological dyslexics as compared to those without this deficit and controls in the left inferior frontal gyrus (area 44: phonological segmentation), the left SMA (area 6), the left precentral gyrus (area 6) and the right insula. Non-phonological dyslexics revealed subtype-specific increased activation in the left supramarginal gyrus (area PFcm; phonological storage) and angular gyrus (area PGp). The study thus provides the first direct evidence for the neurobiological grounding of dyslexia subtypes. Moreover, the data contribute to a better understanding of the frequently encountered heterogeneous neuroimaging results in the field of dyslexia. Elsevier 2013-03-25 /pmc/articles/PMC4054964/ /pubmed/24936406 http://dx.doi.org/10.1016/j.nicl.2013.03.010 Text en © 2013 The Authors http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
van Ermingen-Marbach, Muna
Grande, Marion
Pape-Neumann, Julia
Sass, Katharina
Heim, Stefan
Distinct neural signatures of cognitive subtypes of dyslexia with and without phonological deficits()
title Distinct neural signatures of cognitive subtypes of dyslexia with and without phonological deficits()
title_full Distinct neural signatures of cognitive subtypes of dyslexia with and without phonological deficits()
title_fullStr Distinct neural signatures of cognitive subtypes of dyslexia with and without phonological deficits()
title_full_unstemmed Distinct neural signatures of cognitive subtypes of dyslexia with and without phonological deficits()
title_short Distinct neural signatures of cognitive subtypes of dyslexia with and without phonological deficits()
title_sort distinct neural signatures of cognitive subtypes of dyslexia with and without phonological deficits()
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054964/
https://www.ncbi.nlm.nih.gov/pubmed/24936406
http://dx.doi.org/10.1016/j.nicl.2013.03.010
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