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Relationship between Stroke Volume and Pulse Pressure during Blood Volume Perturbation: A Mathematical Analysis
Arterial pulse pressure has been widely used as surrogate of stroke volume, for example, in the guidance of fluid therapy. However, recent experimental investigations suggest that arterial pulse pressure is not linearly proportional to stroke volume. However, mechanisms underlying the relation betwe...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054969/ https://www.ncbi.nlm.nih.gov/pubmed/25006577 http://dx.doi.org/10.1155/2014/459269 |
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author | Bighamian, Ramin Hahn, Jin-Oh |
author_facet | Bighamian, Ramin Hahn, Jin-Oh |
author_sort | Bighamian, Ramin |
collection | PubMed |
description | Arterial pulse pressure has been widely used as surrogate of stroke volume, for example, in the guidance of fluid therapy. However, recent experimental investigations suggest that arterial pulse pressure is not linearly proportional to stroke volume. However, mechanisms underlying the relation between the two have not been clearly understood. The goal of this study was to elucidate how arterial pulse pressure and stroke volume respond to a perturbation in the left ventricular blood volume based on a systematic mathematical analysis. Both our mathematical analysis and experimental data showed that the relative change in arterial pulse pressure due to a left ventricular blood volume perturbation was consistently smaller than the corresponding relative change in stroke volume, due to the nonlinear left ventricular pressure-volume relation during diastole that reduces the sensitivity of arterial pulse pressure to perturbations in the left ventricular blood volume. Therefore, arterial pulse pressure must be used with care when used as surrogate of stroke volume in guiding fluid therapy. |
format | Online Article Text |
id | pubmed-4054969 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40549692014-07-08 Relationship between Stroke Volume and Pulse Pressure during Blood Volume Perturbation: A Mathematical Analysis Bighamian, Ramin Hahn, Jin-Oh Biomed Res Int Research Article Arterial pulse pressure has been widely used as surrogate of stroke volume, for example, in the guidance of fluid therapy. However, recent experimental investigations suggest that arterial pulse pressure is not linearly proportional to stroke volume. However, mechanisms underlying the relation between the two have not been clearly understood. The goal of this study was to elucidate how arterial pulse pressure and stroke volume respond to a perturbation in the left ventricular blood volume based on a systematic mathematical analysis. Both our mathematical analysis and experimental data showed that the relative change in arterial pulse pressure due to a left ventricular blood volume perturbation was consistently smaller than the corresponding relative change in stroke volume, due to the nonlinear left ventricular pressure-volume relation during diastole that reduces the sensitivity of arterial pulse pressure to perturbations in the left ventricular blood volume. Therefore, arterial pulse pressure must be used with care when used as surrogate of stroke volume in guiding fluid therapy. Hindawi Publishing Corporation 2014 2014-05-20 /pmc/articles/PMC4054969/ /pubmed/25006577 http://dx.doi.org/10.1155/2014/459269 Text en Copyright © 2014 R. Bighamian and J.-O. Hahn. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Bighamian, Ramin Hahn, Jin-Oh Relationship between Stroke Volume and Pulse Pressure during Blood Volume Perturbation: A Mathematical Analysis |
title | Relationship between Stroke Volume and Pulse Pressure during Blood Volume Perturbation: A Mathematical Analysis |
title_full | Relationship between Stroke Volume and Pulse Pressure during Blood Volume Perturbation: A Mathematical Analysis |
title_fullStr | Relationship between Stroke Volume and Pulse Pressure during Blood Volume Perturbation: A Mathematical Analysis |
title_full_unstemmed | Relationship between Stroke Volume and Pulse Pressure during Blood Volume Perturbation: A Mathematical Analysis |
title_short | Relationship between Stroke Volume and Pulse Pressure during Blood Volume Perturbation: A Mathematical Analysis |
title_sort | relationship between stroke volume and pulse pressure during blood volume perturbation: a mathematical analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054969/ https://www.ncbi.nlm.nih.gov/pubmed/25006577 http://dx.doi.org/10.1155/2014/459269 |
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