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Protein recycling pathways in neurodegenerative diseases
Many progressive neurodegenerative diseases, including Alzheimer disease, Parkinson disease, Huntington disease, amyotrophic lateral sclerosis, and frontotemporal lobe dementia, are associated with the formation of insoluble intracellular proteinaceous inclusions. It is therefore imperative to under...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055009/ https://www.ncbi.nlm.nih.gov/pubmed/25031631 http://dx.doi.org/10.1186/alzrt243 |
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author | Fecto, Faisal Esengul, Y Taylan Siddique, Teepu |
author_facet | Fecto, Faisal Esengul, Y Taylan Siddique, Teepu |
author_sort | Fecto, Faisal |
collection | PubMed |
description | Many progressive neurodegenerative diseases, including Alzheimer disease, Parkinson disease, Huntington disease, amyotrophic lateral sclerosis, and frontotemporal lobe dementia, are associated with the formation of insoluble intracellular proteinaceous inclusions. It is therefore imperative to understand the factors that regulate normal, as well as abnormal, protein recycling in neurons. Dysfunction of the ubiquitin-proteasome or autophagy pathways might contribute to the pathology of various neurodegenerative diseases. Induction of these pathways may offer a rational therapeutic strategy for a number of these diseases. |
format | Online Article Text |
id | pubmed-4055009 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-40550092015-03-06 Protein recycling pathways in neurodegenerative diseases Fecto, Faisal Esengul, Y Taylan Siddique, Teepu Alzheimers Res Ther Review Many progressive neurodegenerative diseases, including Alzheimer disease, Parkinson disease, Huntington disease, amyotrophic lateral sclerosis, and frontotemporal lobe dementia, are associated with the formation of insoluble intracellular proteinaceous inclusions. It is therefore imperative to understand the factors that regulate normal, as well as abnormal, protein recycling in neurons. Dysfunction of the ubiquitin-proteasome or autophagy pathways might contribute to the pathology of various neurodegenerative diseases. Induction of these pathways may offer a rational therapeutic strategy for a number of these diseases. BioMed Central 2014-03-06 /pmc/articles/PMC4055009/ /pubmed/25031631 http://dx.doi.org/10.1186/alzrt243 Text en Copyright © 2014 Fecto et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 The licensee has exclusive rights to distribute this article, in any medium, for 12 months following its publication. After this time, the article is available under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Fecto, Faisal Esengul, Y Taylan Siddique, Teepu Protein recycling pathways in neurodegenerative diseases |
title | Protein recycling pathways in neurodegenerative diseases |
title_full | Protein recycling pathways in neurodegenerative diseases |
title_fullStr | Protein recycling pathways in neurodegenerative diseases |
title_full_unstemmed | Protein recycling pathways in neurodegenerative diseases |
title_short | Protein recycling pathways in neurodegenerative diseases |
title_sort | protein recycling pathways in neurodegenerative diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055009/ https://www.ncbi.nlm.nih.gov/pubmed/25031631 http://dx.doi.org/10.1186/alzrt243 |
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