Cargando…

Protein recycling pathways in neurodegenerative diseases

Many progressive neurodegenerative diseases, including Alzheimer disease, Parkinson disease, Huntington disease, amyotrophic lateral sclerosis, and frontotemporal lobe dementia, are associated with the formation of insoluble intracellular proteinaceous inclusions. It is therefore imperative to under...

Descripción completa

Detalles Bibliográficos
Autores principales: Fecto, Faisal, Esengul, Y Taylan, Siddique, Teepu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055009/
https://www.ncbi.nlm.nih.gov/pubmed/25031631
http://dx.doi.org/10.1186/alzrt243
_version_ 1782320580762009600
author Fecto, Faisal
Esengul, Y Taylan
Siddique, Teepu
author_facet Fecto, Faisal
Esengul, Y Taylan
Siddique, Teepu
author_sort Fecto, Faisal
collection PubMed
description Many progressive neurodegenerative diseases, including Alzheimer disease, Parkinson disease, Huntington disease, amyotrophic lateral sclerosis, and frontotemporal lobe dementia, are associated with the formation of insoluble intracellular proteinaceous inclusions. It is therefore imperative to understand the factors that regulate normal, as well as abnormal, protein recycling in neurons. Dysfunction of the ubiquitin-proteasome or autophagy pathways might contribute to the pathology of various neurodegenerative diseases. Induction of these pathways may offer a rational therapeutic strategy for a number of these diseases.
format Online
Article
Text
id pubmed-4055009
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-40550092015-03-06 Protein recycling pathways in neurodegenerative diseases Fecto, Faisal Esengul, Y Taylan Siddique, Teepu Alzheimers Res Ther Review Many progressive neurodegenerative diseases, including Alzheimer disease, Parkinson disease, Huntington disease, amyotrophic lateral sclerosis, and frontotemporal lobe dementia, are associated with the formation of insoluble intracellular proteinaceous inclusions. It is therefore imperative to understand the factors that regulate normal, as well as abnormal, protein recycling in neurons. Dysfunction of the ubiquitin-proteasome or autophagy pathways might contribute to the pathology of various neurodegenerative diseases. Induction of these pathways may offer a rational therapeutic strategy for a number of these diseases. BioMed Central 2014-03-06 /pmc/articles/PMC4055009/ /pubmed/25031631 http://dx.doi.org/10.1186/alzrt243 Text en Copyright © 2014 Fecto et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 The licensee has exclusive rights to distribute this article, in any medium, for 12 months following its publication. After this time, the article is available under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Fecto, Faisal
Esengul, Y Taylan
Siddique, Teepu
Protein recycling pathways in neurodegenerative diseases
title Protein recycling pathways in neurodegenerative diseases
title_full Protein recycling pathways in neurodegenerative diseases
title_fullStr Protein recycling pathways in neurodegenerative diseases
title_full_unstemmed Protein recycling pathways in neurodegenerative diseases
title_short Protein recycling pathways in neurodegenerative diseases
title_sort protein recycling pathways in neurodegenerative diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055009/
https://www.ncbi.nlm.nih.gov/pubmed/25031631
http://dx.doi.org/10.1186/alzrt243
work_keys_str_mv AT fectofaisal proteinrecyclingpathwaysinneurodegenerativediseases
AT esengulytaylan proteinrecyclingpathwaysinneurodegenerativediseases
AT siddiqueteepu proteinrecyclingpathwaysinneurodegenerativediseases