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Metadherin, p50, and p65 Expression in Epithelial Ovarian Neoplasms: An Immunohistochemical Study

NF-κB signaling promotes cancer progression in a large number of malignancies. Metadherin, a coactivator of the NF-κB transcription complex, was recently identified to regulate different signaling pathways that are closely related to cancer. We assessed the immunohistochemical expression of p50, p65...

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Autores principales: Giopanou, Ioanna, Bravou, Vasiliki, Papanastasopoulos, Panagiotis, Lilis, Ioannis, Aroukatos, Panagiotis, Papachristou, Dionysios, Kounelis, Sophia, Papadaki, Helen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055019/
https://www.ncbi.nlm.nih.gov/pubmed/24963474
http://dx.doi.org/10.1155/2014/178410
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author Giopanou, Ioanna
Bravou, Vasiliki
Papanastasopoulos, Panagiotis
Lilis, Ioannis
Aroukatos, Panagiotis
Papachristou, Dionysios
Kounelis, Sophia
Papadaki, Helen
author_facet Giopanou, Ioanna
Bravou, Vasiliki
Papanastasopoulos, Panagiotis
Lilis, Ioannis
Aroukatos, Panagiotis
Papachristou, Dionysios
Kounelis, Sophia
Papadaki, Helen
author_sort Giopanou, Ioanna
collection PubMed
description NF-κB signaling promotes cancer progression in a large number of malignancies. Metadherin, a coactivator of the NF-κB transcription complex, was recently identified to regulate different signaling pathways that are closely related to cancer. We assessed the immunohistochemical expression of p50, p65, and metadherin in 30 ovarian carcinomas, 15 borderline ovarian tumours, and 31 benign ovarian cystadenomas. Ovarian carcinomas exhibited significantly higher expression of all 3 markers compared to benign ovarian tumours. Borderline ovarian tumours demonstrated significantly higher expression for all 3 markers compared to benign cystadenomas. Ovarian carcinomas demonstrated significantly higher expression of p50 and metadherin compared to borderline ovarian tumours, whereas no significant difference was noted in p65 expression between ovarian carcinomas and borderline ovarian tumours. There was a strong correlation with the expression levels of p50, p65, and metadherin, whereas no correlation was observed with either grade or stage. Strong p50, p65, and metadherin expression was associated with a high probability to distinguish ovarian carcinomas over borderline and benign ovarian tumours, as well as borderline ovarian tumours over benign ovarian neoplasms. A gradual increase in the expression of these molecules is noted when moving across the spectrum of ovarian carcinogenesis, from borderline ovarian tumours to epithelial carcinomas.
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spelling pubmed-40550192014-06-24 Metadherin, p50, and p65 Expression in Epithelial Ovarian Neoplasms: An Immunohistochemical Study Giopanou, Ioanna Bravou, Vasiliki Papanastasopoulos, Panagiotis Lilis, Ioannis Aroukatos, Panagiotis Papachristou, Dionysios Kounelis, Sophia Papadaki, Helen Biomed Res Int Research Article NF-κB signaling promotes cancer progression in a large number of malignancies. Metadherin, a coactivator of the NF-κB transcription complex, was recently identified to regulate different signaling pathways that are closely related to cancer. We assessed the immunohistochemical expression of p50, p65, and metadherin in 30 ovarian carcinomas, 15 borderline ovarian tumours, and 31 benign ovarian cystadenomas. Ovarian carcinomas exhibited significantly higher expression of all 3 markers compared to benign ovarian tumours. Borderline ovarian tumours demonstrated significantly higher expression for all 3 markers compared to benign cystadenomas. Ovarian carcinomas demonstrated significantly higher expression of p50 and metadherin compared to borderline ovarian tumours, whereas no significant difference was noted in p65 expression between ovarian carcinomas and borderline ovarian tumours. There was a strong correlation with the expression levels of p50, p65, and metadherin, whereas no correlation was observed with either grade or stage. Strong p50, p65, and metadherin expression was associated with a high probability to distinguish ovarian carcinomas over borderline and benign ovarian tumours, as well as borderline ovarian tumours over benign ovarian neoplasms. A gradual increase in the expression of these molecules is noted when moving across the spectrum of ovarian carcinogenesis, from borderline ovarian tumours to epithelial carcinomas. Hindawi Publishing Corporation 2014 2014-05-22 /pmc/articles/PMC4055019/ /pubmed/24963474 http://dx.doi.org/10.1155/2014/178410 Text en Copyright © 2014 Ioanna Giopanou et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Giopanou, Ioanna
Bravou, Vasiliki
Papanastasopoulos, Panagiotis
Lilis, Ioannis
Aroukatos, Panagiotis
Papachristou, Dionysios
Kounelis, Sophia
Papadaki, Helen
Metadherin, p50, and p65 Expression in Epithelial Ovarian Neoplasms: An Immunohistochemical Study
title Metadherin, p50, and p65 Expression in Epithelial Ovarian Neoplasms: An Immunohistochemical Study
title_full Metadherin, p50, and p65 Expression in Epithelial Ovarian Neoplasms: An Immunohistochemical Study
title_fullStr Metadherin, p50, and p65 Expression in Epithelial Ovarian Neoplasms: An Immunohistochemical Study
title_full_unstemmed Metadherin, p50, and p65 Expression in Epithelial Ovarian Neoplasms: An Immunohistochemical Study
title_short Metadherin, p50, and p65 Expression in Epithelial Ovarian Neoplasms: An Immunohistochemical Study
title_sort metadherin, p50, and p65 expression in epithelial ovarian neoplasms: an immunohistochemical study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055019/
https://www.ncbi.nlm.nih.gov/pubmed/24963474
http://dx.doi.org/10.1155/2014/178410
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