Cargando…
Brugada Syndrome and Pregnancy: Highlights on Antenatal and Prenatal Management
Introduction. Brugada syndrome is characterized by a disruption of heart's normal rhythm. It is an autosomal dominant disease due to a mutation of SNC5A gene. Its prevalence is low all over the world, but it is a lethal disease. Sudden cardiac death is the result of phenotypic manifestation of...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055041/ https://www.ncbi.nlm.nih.gov/pubmed/24963427 http://dx.doi.org/10.1155/2014/531648 |
_version_ | 1782320585516253184 |
---|---|
author | Giambanco, Laura Incandela, Domenico Maiorana, Antonio Alio, Walter Alio, Luigi |
author_facet | Giambanco, Laura Incandela, Domenico Maiorana, Antonio Alio, Walter Alio, Luigi |
author_sort | Giambanco, Laura |
collection | PubMed |
description | Introduction. Brugada syndrome is characterized by a disruption of heart's normal rhythm. It is an autosomal dominant disease due to a mutation of SNC5A gene. Its prevalence is low all over the world, but it is a lethal disease. Sudden cardiac death is the result of phenotypic manifestation of Brugada syndrome. Among asymptomatic Brugada patients, arrhythmia could be provoked by physical activity, fever, or pregnancy. About obstetrical management, very few data or reports have been published since this syndrome has been diagnosed in late 1992. Case Presentation. A 20-year-old pregnant woman at 13 weeks of gestation was referred to our department because of her familial history of sudden cardiac deaths. Brothers and sisters of her mother died of Brugada syndrome in childhood or older and live components of this family were carrier of mutation in Brugada gene. The pregnancy was uneventful. The patient gave birth vaginally without any arrhythmia. Strictly cardiological monitoring was performed during labour, delivery, and 12 hours of the postpartum. Conclusion. Even though patient at low risk may never have arrhythmia, some conditions could represent a Brugada trigger. The management could be very easy and uneventful. Otherwise it could be very difficult with need of ECMO or antiarrhythmics drugs or intracardiac device. Obstetrical management of Brugada pregnant women should be very strict and multidisciplinary in cooperation with cardiologist and anaesthesiologist and should provide an informed consent to the couple. |
format | Online Article Text |
id | pubmed-4055041 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40550412014-06-24 Brugada Syndrome and Pregnancy: Highlights on Antenatal and Prenatal Management Giambanco, Laura Incandela, Domenico Maiorana, Antonio Alio, Walter Alio, Luigi Case Rep Obstet Gynecol Case Report Introduction. Brugada syndrome is characterized by a disruption of heart's normal rhythm. It is an autosomal dominant disease due to a mutation of SNC5A gene. Its prevalence is low all over the world, but it is a lethal disease. Sudden cardiac death is the result of phenotypic manifestation of Brugada syndrome. Among asymptomatic Brugada patients, arrhythmia could be provoked by physical activity, fever, or pregnancy. About obstetrical management, very few data or reports have been published since this syndrome has been diagnosed in late 1992. Case Presentation. A 20-year-old pregnant woman at 13 weeks of gestation was referred to our department because of her familial history of sudden cardiac deaths. Brothers and sisters of her mother died of Brugada syndrome in childhood or older and live components of this family were carrier of mutation in Brugada gene. The pregnancy was uneventful. The patient gave birth vaginally without any arrhythmia. Strictly cardiological monitoring was performed during labour, delivery, and 12 hours of the postpartum. Conclusion. Even though patient at low risk may never have arrhythmia, some conditions could represent a Brugada trigger. The management could be very easy and uneventful. Otherwise it could be very difficult with need of ECMO or antiarrhythmics drugs or intracardiac device. Obstetrical management of Brugada pregnant women should be very strict and multidisciplinary in cooperation with cardiologist and anaesthesiologist and should provide an informed consent to the couple. Hindawi Publishing Corporation 2014 2014-05-22 /pmc/articles/PMC4055041/ /pubmed/24963427 http://dx.doi.org/10.1155/2014/531648 Text en Copyright © 2014 Laura Giambanco et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Giambanco, Laura Incandela, Domenico Maiorana, Antonio Alio, Walter Alio, Luigi Brugada Syndrome and Pregnancy: Highlights on Antenatal and Prenatal Management |
title | Brugada Syndrome and Pregnancy: Highlights on Antenatal and Prenatal Management |
title_full | Brugada Syndrome and Pregnancy: Highlights on Antenatal and Prenatal Management |
title_fullStr | Brugada Syndrome and Pregnancy: Highlights on Antenatal and Prenatal Management |
title_full_unstemmed | Brugada Syndrome and Pregnancy: Highlights on Antenatal and Prenatal Management |
title_short | Brugada Syndrome and Pregnancy: Highlights on Antenatal and Prenatal Management |
title_sort | brugada syndrome and pregnancy: highlights on antenatal and prenatal management |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055041/ https://www.ncbi.nlm.nih.gov/pubmed/24963427 http://dx.doi.org/10.1155/2014/531648 |
work_keys_str_mv | AT giambancolaura brugadasyndromeandpregnancyhighlightsonantenatalandprenatalmanagement AT incandeladomenico brugadasyndromeandpregnancyhighlightsonantenatalandprenatalmanagement AT maioranaantonio brugadasyndromeandpregnancyhighlightsonantenatalandprenatalmanagement AT aliowalter brugadasyndromeandpregnancyhighlightsonantenatalandprenatalmanagement AT alioluigi brugadasyndromeandpregnancyhighlightsonantenatalandprenatalmanagement |