Induction of Stemlike Cells with Fibrogenic Properties by Carbon Nanotubes and Its Role in Fibrogenesis

[Image: see text] We developed a three-dimensional fibroblastic nodule model for fibrogenicity testing of nanomaterials and investigated the role of fibroblast stemlike cells (FSCs) in the fibrogenic process. We showed that carbon nanotubes (CNTs) induced fibroblastic nodule formation in primary hum...

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Autores principales: Luanpitpong, Sudjit, Wang, Liying, Manke, Amruta, Martin, Karen H., Ammer, Amanda Gatesman, Castranova, Vincent, Yang, Yong, Rojansakul, Yon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055043/
https://www.ncbi.nlm.nih.gov/pubmed/24873662
http://dx.doi.org/10.1021/nl5002026
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author Luanpitpong, Sudjit
Wang, Liying
Manke, Amruta
Martin, Karen H.
Ammer, Amanda Gatesman
Castranova, Vincent
Yang, Yong
Rojansakul, Yon
author_facet Luanpitpong, Sudjit
Wang, Liying
Manke, Amruta
Martin, Karen H.
Ammer, Amanda Gatesman
Castranova, Vincent
Yang, Yong
Rojansakul, Yon
author_sort Luanpitpong, Sudjit
collection PubMed
description [Image: see text] We developed a three-dimensional fibroblastic nodule model for fibrogenicity testing of nanomaterials and investigated the role of fibroblast stemlike cells (FSCs) in the fibrogenic process. We showed that carbon nanotubes (CNTs) induced fibroblastic nodule formation in primary human lung fibroblast cultures resembling the fibroblastic foci in clinical fibrosis and promoted FSCs that are highly fibrogenic and a potential driving force of fibrogenesis. This study provides a predictive 3D model and mechanistic insight on CNT fibrogenesis.
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spelling pubmed-40550432015-05-29 Induction of Stemlike Cells with Fibrogenic Properties by Carbon Nanotubes and Its Role in Fibrogenesis Luanpitpong, Sudjit Wang, Liying Manke, Amruta Martin, Karen H. Ammer, Amanda Gatesman Castranova, Vincent Yang, Yong Rojansakul, Yon Nano Lett [Image: see text] We developed a three-dimensional fibroblastic nodule model for fibrogenicity testing of nanomaterials and investigated the role of fibroblast stemlike cells (FSCs) in the fibrogenic process. We showed that carbon nanotubes (CNTs) induced fibroblastic nodule formation in primary human lung fibroblast cultures resembling the fibroblastic foci in clinical fibrosis and promoted FSCs that are highly fibrogenic and a potential driving force of fibrogenesis. This study provides a predictive 3D model and mechanistic insight on CNT fibrogenesis. American Chemical Society 2014-05-29 2014-06-11 /pmc/articles/PMC4055043/ /pubmed/24873662 http://dx.doi.org/10.1021/nl5002026 Text en Copyright © 2014 American Chemical Society
spellingShingle Luanpitpong, Sudjit
Wang, Liying
Manke, Amruta
Martin, Karen H.
Ammer, Amanda Gatesman
Castranova, Vincent
Yang, Yong
Rojansakul, Yon
Induction of Stemlike Cells with Fibrogenic Properties by Carbon Nanotubes and Its Role in Fibrogenesis
title Induction of Stemlike Cells with Fibrogenic Properties by Carbon Nanotubes and Its Role in Fibrogenesis
title_full Induction of Stemlike Cells with Fibrogenic Properties by Carbon Nanotubes and Its Role in Fibrogenesis
title_fullStr Induction of Stemlike Cells with Fibrogenic Properties by Carbon Nanotubes and Its Role in Fibrogenesis
title_full_unstemmed Induction of Stemlike Cells with Fibrogenic Properties by Carbon Nanotubes and Its Role in Fibrogenesis
title_short Induction of Stemlike Cells with Fibrogenic Properties by Carbon Nanotubes and Its Role in Fibrogenesis
title_sort induction of stemlike cells with fibrogenic properties by carbon nanotubes and its role in fibrogenesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055043/
https://www.ncbi.nlm.nih.gov/pubmed/24873662
http://dx.doi.org/10.1021/nl5002026
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