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Exosome in Tumour Microenvironment: Overview of the Crosstalk between Normal and Cancer Cells
Cancer development is a multistep process in which exosomes play important roles. Exosomes are small vesicles formed in vesicular bodies in the endosomal network. The major role of exosomes seems to be the transport of bioactive molecules between cells. Depending on the cell of origin, exosomes are...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055162/ https://www.ncbi.nlm.nih.gov/pubmed/24963475 http://dx.doi.org/10.1155/2014/179486 |
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author | Roma-Rodrigues, Catarina Fernandes, Alexandra R. Baptista, Pedro Viana |
author_facet | Roma-Rodrigues, Catarina Fernandes, Alexandra R. Baptista, Pedro Viana |
author_sort | Roma-Rodrigues, Catarina |
collection | PubMed |
description | Cancer development is a multistep process in which exosomes play important roles. Exosomes are small vesicles formed in vesicular bodies in the endosomal network. The major role of exosomes seems to be the transport of bioactive molecules between cells. Depending on the cell of origin, exosomes are implicated in the regulation of several cellular events, with phenotypic consequences in recipient cells. Cancer derived exosomes (CCEs) are important players in the formation of the tumour microenvironment by (i) enabling the escape of tumour cells to immunological system and help initiating the inflammatory response; (ii) acting in the differentiation of fibroblasts and mesenchymal cells into myofibroblasts; (iii) triggering the angiogenic process; and (iv) enhancing the metastatic evolution of the tumour by promoting epithelial to mesenchymal transformation of tumour cells and by preparing the tumour niche in the new anatomical location. Since the finding that exosomes content resembles that of the cell of origin, they may be regarded as suitable biomarkers for cancer diagnosis, allowing for diagnosis and prognosis via a minimal invasive procedure. Exosome involvement in cancer may open new avenues regarding therapeutics, such as vectors for targeted drug delivery. |
format | Online Article Text |
id | pubmed-4055162 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40551622014-06-24 Exosome in Tumour Microenvironment: Overview of the Crosstalk between Normal and Cancer Cells Roma-Rodrigues, Catarina Fernandes, Alexandra R. Baptista, Pedro Viana Biomed Res Int Review Article Cancer development is a multistep process in which exosomes play important roles. Exosomes are small vesicles formed in vesicular bodies in the endosomal network. The major role of exosomes seems to be the transport of bioactive molecules between cells. Depending on the cell of origin, exosomes are implicated in the regulation of several cellular events, with phenotypic consequences in recipient cells. Cancer derived exosomes (CCEs) are important players in the formation of the tumour microenvironment by (i) enabling the escape of tumour cells to immunological system and help initiating the inflammatory response; (ii) acting in the differentiation of fibroblasts and mesenchymal cells into myofibroblasts; (iii) triggering the angiogenic process; and (iv) enhancing the metastatic evolution of the tumour by promoting epithelial to mesenchymal transformation of tumour cells and by preparing the tumour niche in the new anatomical location. Since the finding that exosomes content resembles that of the cell of origin, they may be regarded as suitable biomarkers for cancer diagnosis, allowing for diagnosis and prognosis via a minimal invasive procedure. Exosome involvement in cancer may open new avenues regarding therapeutics, such as vectors for targeted drug delivery. Hindawi Publishing Corporation 2014 2014-05-21 /pmc/articles/PMC4055162/ /pubmed/24963475 http://dx.doi.org/10.1155/2014/179486 Text en Copyright © 2014 Catarina Roma-Rodrigues et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Roma-Rodrigues, Catarina Fernandes, Alexandra R. Baptista, Pedro Viana Exosome in Tumour Microenvironment: Overview of the Crosstalk between Normal and Cancer Cells |
title | Exosome in Tumour Microenvironment: Overview of the Crosstalk between Normal and Cancer Cells |
title_full | Exosome in Tumour Microenvironment: Overview of the Crosstalk between Normal and Cancer Cells |
title_fullStr | Exosome in Tumour Microenvironment: Overview of the Crosstalk between Normal and Cancer Cells |
title_full_unstemmed | Exosome in Tumour Microenvironment: Overview of the Crosstalk between Normal and Cancer Cells |
title_short | Exosome in Tumour Microenvironment: Overview of the Crosstalk between Normal and Cancer Cells |
title_sort | exosome in tumour microenvironment: overview of the crosstalk between normal and cancer cells |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055162/ https://www.ncbi.nlm.nih.gov/pubmed/24963475 http://dx.doi.org/10.1155/2014/179486 |
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