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Exosome in Tumour Microenvironment: Overview of the Crosstalk between Normal and Cancer Cells

Cancer development is a multistep process in which exosomes play important roles. Exosomes are small vesicles formed in vesicular bodies in the endosomal network. The major role of exosomes seems to be the transport of bioactive molecules between cells. Depending on the cell of origin, exosomes are...

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Detalles Bibliográficos
Autores principales: Roma-Rodrigues, Catarina, Fernandes, Alexandra R., Baptista, Pedro Viana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055162/
https://www.ncbi.nlm.nih.gov/pubmed/24963475
http://dx.doi.org/10.1155/2014/179486
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author Roma-Rodrigues, Catarina
Fernandes, Alexandra R.
Baptista, Pedro Viana
author_facet Roma-Rodrigues, Catarina
Fernandes, Alexandra R.
Baptista, Pedro Viana
author_sort Roma-Rodrigues, Catarina
collection PubMed
description Cancer development is a multistep process in which exosomes play important roles. Exosomes are small vesicles formed in vesicular bodies in the endosomal network. The major role of exosomes seems to be the transport of bioactive molecules between cells. Depending on the cell of origin, exosomes are implicated in the regulation of several cellular events, with phenotypic consequences in recipient cells. Cancer derived exosomes (CCEs) are important players in the formation of the tumour microenvironment by (i) enabling the escape of tumour cells to immunological system and help initiating the inflammatory response; (ii) acting in the differentiation of fibroblasts and mesenchymal cells into myofibroblasts; (iii) triggering the angiogenic process; and (iv) enhancing the metastatic evolution of the tumour by promoting epithelial to mesenchymal transformation of tumour cells and by preparing the tumour niche in the new anatomical location. Since the finding that exosomes content resembles that of the cell of origin, they may be regarded as suitable biomarkers for cancer diagnosis, allowing for diagnosis and prognosis via a minimal invasive procedure. Exosome involvement in cancer may open new avenues regarding therapeutics, such as vectors for targeted drug delivery.
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spelling pubmed-40551622014-06-24 Exosome in Tumour Microenvironment: Overview of the Crosstalk between Normal and Cancer Cells Roma-Rodrigues, Catarina Fernandes, Alexandra R. Baptista, Pedro Viana Biomed Res Int Review Article Cancer development is a multistep process in which exosomes play important roles. Exosomes are small vesicles formed in vesicular bodies in the endosomal network. The major role of exosomes seems to be the transport of bioactive molecules between cells. Depending on the cell of origin, exosomes are implicated in the regulation of several cellular events, with phenotypic consequences in recipient cells. Cancer derived exosomes (CCEs) are important players in the formation of the tumour microenvironment by (i) enabling the escape of tumour cells to immunological system and help initiating the inflammatory response; (ii) acting in the differentiation of fibroblasts and mesenchymal cells into myofibroblasts; (iii) triggering the angiogenic process; and (iv) enhancing the metastatic evolution of the tumour by promoting epithelial to mesenchymal transformation of tumour cells and by preparing the tumour niche in the new anatomical location. Since the finding that exosomes content resembles that of the cell of origin, they may be regarded as suitable biomarkers for cancer diagnosis, allowing for diagnosis and prognosis via a minimal invasive procedure. Exosome involvement in cancer may open new avenues regarding therapeutics, such as vectors for targeted drug delivery. Hindawi Publishing Corporation 2014 2014-05-21 /pmc/articles/PMC4055162/ /pubmed/24963475 http://dx.doi.org/10.1155/2014/179486 Text en Copyright © 2014 Catarina Roma-Rodrigues et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Roma-Rodrigues, Catarina
Fernandes, Alexandra R.
Baptista, Pedro Viana
Exosome in Tumour Microenvironment: Overview of the Crosstalk between Normal and Cancer Cells
title Exosome in Tumour Microenvironment: Overview of the Crosstalk between Normal and Cancer Cells
title_full Exosome in Tumour Microenvironment: Overview of the Crosstalk between Normal and Cancer Cells
title_fullStr Exosome in Tumour Microenvironment: Overview of the Crosstalk between Normal and Cancer Cells
title_full_unstemmed Exosome in Tumour Microenvironment: Overview of the Crosstalk between Normal and Cancer Cells
title_short Exosome in Tumour Microenvironment: Overview of the Crosstalk between Normal and Cancer Cells
title_sort exosome in tumour microenvironment: overview of the crosstalk between normal and cancer cells
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055162/
https://www.ncbi.nlm.nih.gov/pubmed/24963475
http://dx.doi.org/10.1155/2014/179486
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