Prolonged Nitric Oxide Exposure Enhances Anoikis Resistance and Migration through Epithelial-Mesenchymal Transition and Caveolin-1 Upregulation

Nitric oxide (NO) in tumor microenvironment may have a significant impact on metastatic behaviors of cancer. Noncytotoxic doses of NO enhanced anoikis resistance and migration in lung cancer H23 cells via an increase in lamellipodia, epithelial-mesenchymal transition (EMT) markers including vimentin...

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Autores principales: Chanvorachote, Pithi, Pongrakhananon, Varisa, Chunhacha, Preedakorn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055163/
https://www.ncbi.nlm.nih.gov/pubmed/24967418
http://dx.doi.org/10.1155/2014/941359
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author Chanvorachote, Pithi
Pongrakhananon, Varisa
Chunhacha, Preedakorn
author_facet Chanvorachote, Pithi
Pongrakhananon, Varisa
Chunhacha, Preedakorn
author_sort Chanvorachote, Pithi
collection PubMed
description Nitric oxide (NO) in tumor microenvironment may have a significant impact on metastatic behaviors of cancer. Noncytotoxic doses of NO enhanced anoikis resistance and migration in lung cancer H23 cells via an increase in lamellipodia, epithelial-mesenchymal transition (EMT) markers including vimentin and snail, and caveolin-1 (Cav-1). However, the induction of EMT was found in Cav-1-knock down cells treated with NO, suggesting that EMT was through Cav-1-independent pathway. These effects of NO were consistently observed in other lung cancer cells including H292 and H460 cells. These findings highlight the novel role of NO on EMT and metastatic behaviors of cancer cells.
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spelling pubmed-40551632014-06-25 Prolonged Nitric Oxide Exposure Enhances Anoikis Resistance and Migration through Epithelial-Mesenchymal Transition and Caveolin-1 Upregulation Chanvorachote, Pithi Pongrakhananon, Varisa Chunhacha, Preedakorn Biomed Res Int Research Article Nitric oxide (NO) in tumor microenvironment may have a significant impact on metastatic behaviors of cancer. Noncytotoxic doses of NO enhanced anoikis resistance and migration in lung cancer H23 cells via an increase in lamellipodia, epithelial-mesenchymal transition (EMT) markers including vimentin and snail, and caveolin-1 (Cav-1). However, the induction of EMT was found in Cav-1-knock down cells treated with NO, suggesting that EMT was through Cav-1-independent pathway. These effects of NO were consistently observed in other lung cancer cells including H292 and H460 cells. These findings highlight the novel role of NO on EMT and metastatic behaviors of cancer cells. Hindawi Publishing Corporation 2014 2014-05-20 /pmc/articles/PMC4055163/ /pubmed/24967418 http://dx.doi.org/10.1155/2014/941359 Text en Copyright © 2014 Pithi Chanvorachote et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chanvorachote, Pithi
Pongrakhananon, Varisa
Chunhacha, Preedakorn
Prolonged Nitric Oxide Exposure Enhances Anoikis Resistance and Migration through Epithelial-Mesenchymal Transition and Caveolin-1 Upregulation
title Prolonged Nitric Oxide Exposure Enhances Anoikis Resistance and Migration through Epithelial-Mesenchymal Transition and Caveolin-1 Upregulation
title_full Prolonged Nitric Oxide Exposure Enhances Anoikis Resistance and Migration through Epithelial-Mesenchymal Transition and Caveolin-1 Upregulation
title_fullStr Prolonged Nitric Oxide Exposure Enhances Anoikis Resistance and Migration through Epithelial-Mesenchymal Transition and Caveolin-1 Upregulation
title_full_unstemmed Prolonged Nitric Oxide Exposure Enhances Anoikis Resistance and Migration through Epithelial-Mesenchymal Transition and Caveolin-1 Upregulation
title_short Prolonged Nitric Oxide Exposure Enhances Anoikis Resistance and Migration through Epithelial-Mesenchymal Transition and Caveolin-1 Upregulation
title_sort prolonged nitric oxide exposure enhances anoikis resistance and migration through epithelial-mesenchymal transition and caveolin-1 upregulation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055163/
https://www.ncbi.nlm.nih.gov/pubmed/24967418
http://dx.doi.org/10.1155/2014/941359
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AT chunhachapreedakorn prolongednitricoxideexposureenhancesanoikisresistanceandmigrationthroughepithelialmesenchymaltransitionandcaveolin1upregulation

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