Cargando…

Noncontinuous use of antidepressant in adults with major depressive disorders – a retrospective cohort study

BACKGROUND: Noncontinuous antidepressant use is frequently observed in clinical practice despite the standard recommendation of at least 6–9 months of continuous treatment. The problem may be more serious in Chinese populations where stigmatization is common. This retrospective cohort study investig...

Descripción completa

Detalles Bibliográficos
Autores principales: Yau, Wai-Yin, Chan, Man-Chi, Wing, Yun-Kwok, Lam, Ho-Bun, Lin, Wei, Lam, Siu-Ping, Lee, Chui-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055189/
https://www.ncbi.nlm.nih.gov/pubmed/24944868
http://dx.doi.org/10.1002/brb3.224
_version_ 1782320617798762496
author Yau, Wai-Yin
Chan, Man-Chi
Wing, Yun-Kwok
Lam, Ho-Bun
Lin, Wei
Lam, Siu-Ping
Lee, Chui-Ping
author_facet Yau, Wai-Yin
Chan, Man-Chi
Wing, Yun-Kwok
Lam, Ho-Bun
Lin, Wei
Lam, Siu-Ping
Lee, Chui-Ping
author_sort Yau, Wai-Yin
collection PubMed
description BACKGROUND: Noncontinuous antidepressant use is frequently observed in clinical practice despite the standard recommendation of at least 6–9 months of continuous treatment. The problem may be more serious in Chinese populations where stigmatization is common. This retrospective cohort study investigated the rate of noncontinuous antidepressant use and subsequent rate of relapse and recurrence in psychiatric Chinese outpatients by examining the prescription records, electronic medical records, and written medical records. Factors associated with noncontinuous antidepressant use were also identified. METHODS: We reviewed the medical records of 189 patients newly dispensed with an antidepressant in the psychiatric outpatient clinic during year 2006 and 2007. Primary outcome was the rate of noncontinuous antidepressant use within 6 months of therapy. Secondary outcomes included the factors associated with noncontinuous antidepressant use and the rate of subsequent depression relapse and recurrence within 1 year of starting treatment. RESULTS: Among the 189 subjects included in this study, 46% were noncontinuous users of the newly prescribed antidepressant therapy. The noncontinuous users were found to have an eightfold increase (OR: 8.42, 95% CI: 3.30–21.47) in the risks of relapse/recurrence depressive episodes within 1 year after treatment initiation. Younger age (P = 0.008), female, (P = 0.029), residency in public housing estate (P = 0.029), experiencing side effects (P = 0.024), infrequent follow-ups (P = 0.006), and earlier onset of diagnosis (P = 0.034) were factors significantly associated with noncontinuous antidepressant use. CONCLUSIONS: Noncontinuous antidepressant use is common in the local Chinese depressive patients and associated with a high rate of relapse and recurrence. Collaborative multidisciplinary approaches that target patient education and enhancement of follow-up adherence are needed.
format Online
Article
Text
id pubmed-4055189
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher BlackWell Publishing Ltd
record_format MEDLINE/PubMed
spelling pubmed-40551892014-06-18 Noncontinuous use of antidepressant in adults with major depressive disorders – a retrospective cohort study Yau, Wai-Yin Chan, Man-Chi Wing, Yun-Kwok Lam, Ho-Bun Lin, Wei Lam, Siu-Ping Lee, Chui-Ping Brain Behav Original Research BACKGROUND: Noncontinuous antidepressant use is frequently observed in clinical practice despite the standard recommendation of at least 6–9 months of continuous treatment. The problem may be more serious in Chinese populations where stigmatization is common. This retrospective cohort study investigated the rate of noncontinuous antidepressant use and subsequent rate of relapse and recurrence in psychiatric Chinese outpatients by examining the prescription records, electronic medical records, and written medical records. Factors associated with noncontinuous antidepressant use were also identified. METHODS: We reviewed the medical records of 189 patients newly dispensed with an antidepressant in the psychiatric outpatient clinic during year 2006 and 2007. Primary outcome was the rate of noncontinuous antidepressant use within 6 months of therapy. Secondary outcomes included the factors associated with noncontinuous antidepressant use and the rate of subsequent depression relapse and recurrence within 1 year of starting treatment. RESULTS: Among the 189 subjects included in this study, 46% were noncontinuous users of the newly prescribed antidepressant therapy. The noncontinuous users were found to have an eightfold increase (OR: 8.42, 95% CI: 3.30–21.47) in the risks of relapse/recurrence depressive episodes within 1 year after treatment initiation. Younger age (P = 0.008), female, (P = 0.029), residency in public housing estate (P = 0.029), experiencing side effects (P = 0.024), infrequent follow-ups (P = 0.006), and earlier onset of diagnosis (P = 0.034) were factors significantly associated with noncontinuous antidepressant use. CONCLUSIONS: Noncontinuous antidepressant use is common in the local Chinese depressive patients and associated with a high rate of relapse and recurrence. Collaborative multidisciplinary approaches that target patient education and enhancement of follow-up adherence are needed. BlackWell Publishing Ltd 2014-05 2014-03-14 /pmc/articles/PMC4055189/ /pubmed/24944868 http://dx.doi.org/10.1002/brb3.224 Text en © 2014 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Yau, Wai-Yin
Chan, Man-Chi
Wing, Yun-Kwok
Lam, Ho-Bun
Lin, Wei
Lam, Siu-Ping
Lee, Chui-Ping
Noncontinuous use of antidepressant in adults with major depressive disorders – a retrospective cohort study
title Noncontinuous use of antidepressant in adults with major depressive disorders – a retrospective cohort study
title_full Noncontinuous use of antidepressant in adults with major depressive disorders – a retrospective cohort study
title_fullStr Noncontinuous use of antidepressant in adults with major depressive disorders – a retrospective cohort study
title_full_unstemmed Noncontinuous use of antidepressant in adults with major depressive disorders – a retrospective cohort study
title_short Noncontinuous use of antidepressant in adults with major depressive disorders – a retrospective cohort study
title_sort noncontinuous use of antidepressant in adults with major depressive disorders – a retrospective cohort study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055189/
https://www.ncbi.nlm.nih.gov/pubmed/24944868
http://dx.doi.org/10.1002/brb3.224
work_keys_str_mv AT yauwaiyin noncontinuoususeofantidepressantinadultswithmajordepressivedisordersaretrospectivecohortstudy
AT chanmanchi noncontinuoususeofantidepressantinadultswithmajordepressivedisordersaretrospectivecohortstudy
AT wingyunkwok noncontinuoususeofantidepressantinadultswithmajordepressivedisordersaretrospectivecohortstudy
AT lamhobun noncontinuoususeofantidepressantinadultswithmajordepressivedisordersaretrospectivecohortstudy
AT linwei noncontinuoususeofantidepressantinadultswithmajordepressivedisordersaretrospectivecohortstudy
AT lamsiuping noncontinuoususeofantidepressantinadultswithmajordepressivedisordersaretrospectivecohortstudy
AT leechuiping noncontinuoususeofantidepressantinadultswithmajordepressivedisordersaretrospectivecohortstudy