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Noncontinuous use of antidepressant in adults with major depressive disorders – a retrospective cohort study
BACKGROUND: Noncontinuous antidepressant use is frequently observed in clinical practice despite the standard recommendation of at least 6–9 months of continuous treatment. The problem may be more serious in Chinese populations where stigmatization is common. This retrospective cohort study investig...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BlackWell Publishing Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055189/ https://www.ncbi.nlm.nih.gov/pubmed/24944868 http://dx.doi.org/10.1002/brb3.224 |
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author | Yau, Wai-Yin Chan, Man-Chi Wing, Yun-Kwok Lam, Ho-Bun Lin, Wei Lam, Siu-Ping Lee, Chui-Ping |
author_facet | Yau, Wai-Yin Chan, Man-Chi Wing, Yun-Kwok Lam, Ho-Bun Lin, Wei Lam, Siu-Ping Lee, Chui-Ping |
author_sort | Yau, Wai-Yin |
collection | PubMed |
description | BACKGROUND: Noncontinuous antidepressant use is frequently observed in clinical practice despite the standard recommendation of at least 6–9 months of continuous treatment. The problem may be more serious in Chinese populations where stigmatization is common. This retrospective cohort study investigated the rate of noncontinuous antidepressant use and subsequent rate of relapse and recurrence in psychiatric Chinese outpatients by examining the prescription records, electronic medical records, and written medical records. Factors associated with noncontinuous antidepressant use were also identified. METHODS: We reviewed the medical records of 189 patients newly dispensed with an antidepressant in the psychiatric outpatient clinic during year 2006 and 2007. Primary outcome was the rate of noncontinuous antidepressant use within 6 months of therapy. Secondary outcomes included the factors associated with noncontinuous antidepressant use and the rate of subsequent depression relapse and recurrence within 1 year of starting treatment. RESULTS: Among the 189 subjects included in this study, 46% were noncontinuous users of the newly prescribed antidepressant therapy. The noncontinuous users were found to have an eightfold increase (OR: 8.42, 95% CI: 3.30–21.47) in the risks of relapse/recurrence depressive episodes within 1 year after treatment initiation. Younger age (P = 0.008), female, (P = 0.029), residency in public housing estate (P = 0.029), experiencing side effects (P = 0.024), infrequent follow-ups (P = 0.006), and earlier onset of diagnosis (P = 0.034) were factors significantly associated with noncontinuous antidepressant use. CONCLUSIONS: Noncontinuous antidepressant use is common in the local Chinese depressive patients and associated with a high rate of relapse and recurrence. Collaborative multidisciplinary approaches that target patient education and enhancement of follow-up adherence are needed. |
format | Online Article Text |
id | pubmed-4055189 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BlackWell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-40551892014-06-18 Noncontinuous use of antidepressant in adults with major depressive disorders – a retrospective cohort study Yau, Wai-Yin Chan, Man-Chi Wing, Yun-Kwok Lam, Ho-Bun Lin, Wei Lam, Siu-Ping Lee, Chui-Ping Brain Behav Original Research BACKGROUND: Noncontinuous antidepressant use is frequently observed in clinical practice despite the standard recommendation of at least 6–9 months of continuous treatment. The problem may be more serious in Chinese populations where stigmatization is common. This retrospective cohort study investigated the rate of noncontinuous antidepressant use and subsequent rate of relapse and recurrence in psychiatric Chinese outpatients by examining the prescription records, electronic medical records, and written medical records. Factors associated with noncontinuous antidepressant use were also identified. METHODS: We reviewed the medical records of 189 patients newly dispensed with an antidepressant in the psychiatric outpatient clinic during year 2006 and 2007. Primary outcome was the rate of noncontinuous antidepressant use within 6 months of therapy. Secondary outcomes included the factors associated with noncontinuous antidepressant use and the rate of subsequent depression relapse and recurrence within 1 year of starting treatment. RESULTS: Among the 189 subjects included in this study, 46% were noncontinuous users of the newly prescribed antidepressant therapy. The noncontinuous users were found to have an eightfold increase (OR: 8.42, 95% CI: 3.30–21.47) in the risks of relapse/recurrence depressive episodes within 1 year after treatment initiation. Younger age (P = 0.008), female, (P = 0.029), residency in public housing estate (P = 0.029), experiencing side effects (P = 0.024), infrequent follow-ups (P = 0.006), and earlier onset of diagnosis (P = 0.034) were factors significantly associated with noncontinuous antidepressant use. CONCLUSIONS: Noncontinuous antidepressant use is common in the local Chinese depressive patients and associated with a high rate of relapse and recurrence. Collaborative multidisciplinary approaches that target patient education and enhancement of follow-up adherence are needed. BlackWell Publishing Ltd 2014-05 2014-03-14 /pmc/articles/PMC4055189/ /pubmed/24944868 http://dx.doi.org/10.1002/brb3.224 Text en © 2014 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Yau, Wai-Yin Chan, Man-Chi Wing, Yun-Kwok Lam, Ho-Bun Lin, Wei Lam, Siu-Ping Lee, Chui-Ping Noncontinuous use of antidepressant in adults with major depressive disorders – a retrospective cohort study |
title | Noncontinuous use of antidepressant in adults with major depressive disorders – a retrospective cohort study |
title_full | Noncontinuous use of antidepressant in adults with major depressive disorders – a retrospective cohort study |
title_fullStr | Noncontinuous use of antidepressant in adults with major depressive disorders – a retrospective cohort study |
title_full_unstemmed | Noncontinuous use of antidepressant in adults with major depressive disorders – a retrospective cohort study |
title_short | Noncontinuous use of antidepressant in adults with major depressive disorders – a retrospective cohort study |
title_sort | noncontinuous use of antidepressant in adults with major depressive disorders – a retrospective cohort study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055189/ https://www.ncbi.nlm.nih.gov/pubmed/24944868 http://dx.doi.org/10.1002/brb3.224 |
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