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Effects of Acute Bleeding Followed by Hydroxyethyl Starch 130/0.4 or a Crystalloid on Propofol Concentrations, Cerebral Oxygenation, and Electroencephalographic and Haemodynamic Variables in Pigs

Bleeding changes the haemodynamics, compromising organ perfusion. In this study, the effects of bleeding followed by replacement with hydroxyethyl starch 130/0.4 (HES) or lactated Ringer's (LR) on cerebral oxygenation and electroencephalogram-derived parameters were investigated. Twelve young p...

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Autores principales: Silva, Aura, Ortiz, Ana Liza, Venâncio, Carlos, Souza, Almir P., Ferreira, Luísa Maria, Branco, Paula Sério, de Pinho, Paula Guedes, Amorim, Pedro, Ferreira, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055214/
https://www.ncbi.nlm.nih.gov/pubmed/24971192
http://dx.doi.org/10.1155/2014/710394
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author Silva, Aura
Ortiz, Ana Liza
Venâncio, Carlos
Souza, Almir P.
Ferreira, Luísa Maria
Branco, Paula Sério
de Pinho, Paula Guedes
Amorim, Pedro
Ferreira, David A.
author_facet Silva, Aura
Ortiz, Ana Liza
Venâncio, Carlos
Souza, Almir P.
Ferreira, Luísa Maria
Branco, Paula Sério
de Pinho, Paula Guedes
Amorim, Pedro
Ferreira, David A.
author_sort Silva, Aura
collection PubMed
description Bleeding changes the haemodynamics, compromising organ perfusion. In this study, the effects of bleeding followed by replacement with hydroxyethyl starch 130/0.4 (HES) or lactated Ringer's (LR) on cerebral oxygenation and electroencephalogram-derived parameters were investigated. Twelve young pigs under propofol-remifentanil anaesthesia were bled 30 mL/kg and, after a 20-minute waiting period, volume replacement was performed with HES (G(HES); N = 6) or LR (G(RL); N = 6). Bleeding caused a decrease of more than 50% in mean arterial pressure (P < 0.01) and a decrease in cerebral oximetry (P = 0.039), bispectral index, and electroencephalogram total power (P = 0.04 and P < 0.01, resp.), while propofol plasma concentrations increased (P < 0.01). Both solutions restored the haemodynamics and cerebral oxygenation similarly and were accompanied by an increase in electroencephalogram total power. No differences between groups were found. However, one hour after the end of the volume replacement, the cardiac output (P = 0.03) and the cerebral oxygenation (P = 0.008) decreased in the G(LR) and were significantly lower than in G(HES) (P = 0.02). Volume replacement with HES 130/0.4 was capable of maintaining the cardiac output and cerebral oxygenation during a longer period than LR and caused a decrease in the propofol plasma concentrations.
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spelling pubmed-40552142014-06-26 Effects of Acute Bleeding Followed by Hydroxyethyl Starch 130/0.4 or a Crystalloid on Propofol Concentrations, Cerebral Oxygenation, and Electroencephalographic and Haemodynamic Variables in Pigs Silva, Aura Ortiz, Ana Liza Venâncio, Carlos Souza, Almir P. Ferreira, Luísa Maria Branco, Paula Sério de Pinho, Paula Guedes Amorim, Pedro Ferreira, David A. Vet Med Int Research Article Bleeding changes the haemodynamics, compromising organ perfusion. In this study, the effects of bleeding followed by replacement with hydroxyethyl starch 130/0.4 (HES) or lactated Ringer's (LR) on cerebral oxygenation and electroencephalogram-derived parameters were investigated. Twelve young pigs under propofol-remifentanil anaesthesia were bled 30 mL/kg and, after a 20-minute waiting period, volume replacement was performed with HES (G(HES); N = 6) or LR (G(RL); N = 6). Bleeding caused a decrease of more than 50% in mean arterial pressure (P < 0.01) and a decrease in cerebral oximetry (P = 0.039), bispectral index, and electroencephalogram total power (P = 0.04 and P < 0.01, resp.), while propofol plasma concentrations increased (P < 0.01). Both solutions restored the haemodynamics and cerebral oxygenation similarly and were accompanied by an increase in electroencephalogram total power. No differences between groups were found. However, one hour after the end of the volume replacement, the cardiac output (P = 0.03) and the cerebral oxygenation (P = 0.008) decreased in the G(LR) and were significantly lower than in G(HES) (P = 0.02). Volume replacement with HES 130/0.4 was capable of maintaining the cardiac output and cerebral oxygenation during a longer period than LR and caused a decrease in the propofol plasma concentrations. Hindawi Publishing Corporation 2014 2014-05-19 /pmc/articles/PMC4055214/ /pubmed/24971192 http://dx.doi.org/10.1155/2014/710394 Text en Copyright © 2014 Aura Silva et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Silva, Aura
Ortiz, Ana Liza
Venâncio, Carlos
Souza, Almir P.
Ferreira, Luísa Maria
Branco, Paula Sério
de Pinho, Paula Guedes
Amorim, Pedro
Ferreira, David A.
Effects of Acute Bleeding Followed by Hydroxyethyl Starch 130/0.4 or a Crystalloid on Propofol Concentrations, Cerebral Oxygenation, and Electroencephalographic and Haemodynamic Variables in Pigs
title Effects of Acute Bleeding Followed by Hydroxyethyl Starch 130/0.4 or a Crystalloid on Propofol Concentrations, Cerebral Oxygenation, and Electroencephalographic and Haemodynamic Variables in Pigs
title_full Effects of Acute Bleeding Followed by Hydroxyethyl Starch 130/0.4 or a Crystalloid on Propofol Concentrations, Cerebral Oxygenation, and Electroencephalographic and Haemodynamic Variables in Pigs
title_fullStr Effects of Acute Bleeding Followed by Hydroxyethyl Starch 130/0.4 or a Crystalloid on Propofol Concentrations, Cerebral Oxygenation, and Electroencephalographic and Haemodynamic Variables in Pigs
title_full_unstemmed Effects of Acute Bleeding Followed by Hydroxyethyl Starch 130/0.4 or a Crystalloid on Propofol Concentrations, Cerebral Oxygenation, and Electroencephalographic and Haemodynamic Variables in Pigs
title_short Effects of Acute Bleeding Followed by Hydroxyethyl Starch 130/0.4 or a Crystalloid on Propofol Concentrations, Cerebral Oxygenation, and Electroencephalographic and Haemodynamic Variables in Pigs
title_sort effects of acute bleeding followed by hydroxyethyl starch 130/0.4 or a crystalloid on propofol concentrations, cerebral oxygenation, and electroencephalographic and haemodynamic variables in pigs
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055214/
https://www.ncbi.nlm.nih.gov/pubmed/24971192
http://dx.doi.org/10.1155/2014/710394
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