Cargando…

Estrogen-Related Receptor Alpha Confers Methotrexate Resistance via Attenuation of Reactive Oxygen Species Production and P53 Mediated Apoptosis in Osteosarcoma Cells

Osteosarcoma (OS) is a malignant tumor mainly occurring in children and adolescents. Methotrexate (MTX), a chemotherapy agent, is widely used in treating OS. However, treatment failures are common due to acquired chemoresistance, for which the underlying molecular mechanisms are still unclear. In th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Peng, Wang, Haibin, Duan, Zhijian, Zou, June X., Chen, Hongwu, He, Wei, Wang, Junjian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055217/ https://www.ncbi.nlm.nih.gov/pubmed/24967384 http://dx.doi.org/10.1155/2014/616025

Ejemplares similares

Notopterol Attenuates Estrogen Deficiency-Induced Osteoporosis via Repressing RANKL Signaling and Reactive Oxygen Species
por: Chen, Delong, et al.
Publicado: (2021)

Suppression of Estrogen Receptor Alpha Inhibits Cell Proliferation, Differentiation and Enhances the Chemosensitivity of P53-Positive U2OS Osteosarcoma Cell
por: Wang, Jir-You, et al.
Publicado: (2021)

Identification of genes associated with methotrexate resistance in methotrexate-resistant osteosarcoma cell lines
por: Yang, Xiao-rong, et al.
Publicado: (2015)

Metabolism of Reactive Oxygen Species in Osteosarcoma and Potential Treatment Applications
por: Sun, Wei, et al.
Publicado: (2019)

Transporting Cells in Semi-Solid Gel Condition and at Ambient Temperature
por: Wang, Junjian, et al.
Publicado: (2015)

Patient-derived osteosarcoma cells are resistant to methotrexate
por: dos Santos Cavalcanti, Amanda, et al.
Publicado: (2017)

Methylpiperidinopyrazole Attenuates Estrogen-Induced Mitochondrial Energy Production and Subsequent Osteoblast Maturation via an Estrogen Receptor Alpha-Dependent Mechanism
por: Yeh, Poh-Shiow, et al.
Publicado: (2020)

Impairment of Methotrexate Transport Is Common in Osteosarcoma Tumor Samples
por: Sowers, Rebecca, et al.
Publicado: (2011)

The therapeutic target of estrogen receptor-alpha36 in estrogen-dependent tumors
por: Gu, Yu, et al.
Publicado: (2014)

Mechanisms of methotrexate resistance in osteosarcoma cell lines and strategies for overcoming this resistance
por: WANG, JIANJUN, et al.
Publicado: (2015)

Folate Receptor-Targeting and Reactive Oxygen Species-Responsive Liposomal Formulation of Methotrexate for Treatment of Rheumatoid Arthritis
por: Chen, Minglei, et al.
Publicado: (2019)

Nomogram predicting leukopenia in osteosarcoma after high-dose methotrexate chemotherapy
por: Wu, Haixiao, et al.
Publicado: (2022)

Pharmacogenetic analysis of high-dose methotrexate treatment in children with osteosarcoma
por: Hegyi, Marta, et al.
Publicado: (2016)

P53 functional abnormality in mesenchymal stem cells promotes osteosarcoma development
por: Velletri, T, et al.
Publicado: (2016)

MTHFR variant is associated with high-dose methotrexate-induced toxicity in the Chinese osteosarcoma patients
por: Xu, Leilei, et al.
Publicado: (2018)

Quercetin induced NUPR1-dependent autophagic cell death by disturbing reactive oxygen species homeostasis in osteosarcoma cells
por: Wu, Bowen, et al.
Publicado: (2020)

Hormone-Like Effects of Bisphenol A on p53 and Estrogen Receptor Alpha in Breast Cancer Cells
por: Lloyd, Victoria, et al.
Publicado: (2019)

Estrogen Receptor-Alpha and p53 Status as Regulators of AMPK and mTOR in Luminal Breast Cancer
por: Gandhi, Nishant, et al.
Publicado: (2021)

Delayed High-dose Methotrexate Excretion and Influencing Factors in Osteosarcoma Patients
por: Zhang, Wei, et al.
Publicado: (2016)

Methotrexate Free Chemotherapy and Limb Salvage Surgery for Paediatric Osteosarcoma in India
por: Sukumaran, Reghu Kesavapillai, et al.
Publicado: (2018)

MTHFR Polymorphism Is Associated With Severe Methotrexate-Induced Toxicity in Osteosarcoma Treatment
por: Zhang, Wenchao, et al.
Publicado: (2021)

Co-Delivery of Methotrexate and Nanohydroxyapatite with Polyethylene Glycol Polymers for Chemotherapy of Osteosarcoma
por: Ou, Lingbin, et al.
Publicado: (2023)

Paradox: Curcumin, a Natural Antioxidant, Suppresses Osteosarcoma Cells via Excessive Reactive Oxygen Species
por: Xu, Chunfeng, et al.
Publicado: (2023)

Piscidin-1 Induces Apoptosis via Mitochondrial Reactive Oxygen Species-Regulated Mitochondrial Dysfunction in Human Osteosarcoma Cells
por: Cheng, Meng-Hsuan, et al.
Publicado: (2020)

Macromolecular nanoparticles to attenuate both reactive oxygen species and inflammatory damage for treating Alzheimer's disease
por: Zhang, Bosong, et al.
Publicado: (2022)

Catestatin Protects Against Diastolic Dysfunction by Attenuating Mitochondrial Reactive Oxygen Species Generation
por: Qiu, Zeping, et al.
Publicado: (2023)

Baicalin Attenuates Oxidative Stress in a Tissue-Engineered Liver Model of NAFLD by Scavenging Reactive Oxygen Species
por: Gao, Wen, et al.
Publicado: (2022)

The origins of estrogen receptor alpha-positive and estrogen receptor alpha-negative human breast cancer
por: Allred, D Craig, et al.
Publicado: (2004)

Analysis of the TP53 Deleterious Single Nucleotide Polymorphisms Impact on Estrogen Receptor Alpha-p53 Interaction: A Machine Learning Approach
por: Chitrala, Kumaraswamy Naidu, et al.
Publicado: (2019)

Estrogen and estrogen receptor alpha promotes malignancy and osteoblastic tumorigenesis in prostate cancer
por: Mishra, Sweta, et al.
Publicado: (2015)

Navigating Calcium and Reactive Oxygen Species by Natural Flavones for the Treatment of Heart Failure
por: Yu, Tianhao, et al.
Publicado: (2021)

TP53 in Biology and Treatment of Osteosarcoma
por: Synoradzki, Kamil Jozef, et al.
Publicado: (2021)

Effect of co‐medications and potential risk factors of high‐dose methotrexate‐mediated acute hepatotoxicity in patients with osteosarcoma
por: Wang, Sheng‐Fan, et al.
Publicado: (2023)

Icaritin alleviates docetaxel‐induced skin injury by suppressing reactive oxygen species via estrogen receptors
por: Zou, Jie, et al.
Publicado: (2021)

Correlation between osteosarcoma and the expression of WWOX and p53
por: Liu, Pingtao, et al.
Publicado: (2017)

Hyperthermia Induces Apoptosis through Endoplasmic Reticulum and Reactive Oxygen Species in Human Osteosarcoma Cells
por: Hou, Chun-Han, et al.
Publicado: (2014)

Anticancer effect of (S)-crizotinib on osteosarcoma cells by targeting MTH1 and activating reactive oxygen species
por: Qing, Xiangcheng, et al.
Publicado: (2018)

Safety and efficacy of high‐dose methotrexate for osteosarcoma in adolescents compared with young adults
por: Wippel, Brittany, et al.
Publicado: (2018)

Locally Controlled Release of Methotrexate and Alendronate by Thermo-Sensitive Hydrogels for Synergistic Inhibition of Osteosarcoma Progression
por: Shan, Hongli, et al.
Publicado: (2020)

Severe cellular stress activates apoptosis independently of p53 in osteosarcoma
por: Ho, Cheng-Jung, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_jk2d7pet4rn0hdlam37uluitjg