Cargando…

Antibacterial Activity of Murrayaquinone A and 6-Methoxy-3,7-dimethyl-2,3-dihydro-1H-carbazole-1,4(9H)-dione

The antibacterial activity of Murrayaquinone A (10), a naturally occurring carbazoloquinone alkaloid, and 6-methoxy-3,7-dimethyl-2,3-dihydro-1H-carbazole-1,4(9H)-dione (11), a synthetic carbazoloquinone, both obtained during the development of the synthesis of Carbazomycin G, having unique quinone m...

Descripción completa

Detalles Bibliográficos
Autores principales: Chakraborty, Biswanath, Chakraborty, Suchandra, Saha, Chandan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055288/
https://www.ncbi.nlm.nih.gov/pubmed/24963299
http://dx.doi.org/10.1155/2014/540208
_version_ 1782320637176446976
author Chakraborty, Biswanath
Chakraborty, Suchandra
Saha, Chandan
author_facet Chakraborty, Biswanath
Chakraborty, Suchandra
Saha, Chandan
author_sort Chakraborty, Biswanath
collection PubMed
description The antibacterial activity of Murrayaquinone A (10), a naturally occurring carbazoloquinone alkaloid, and 6-methoxy-3,7-dimethyl-2,3-dihydro-1H-carbazole-1,4(9H)-dione (11), a synthetic carbazoloquinone, both obtained during the development of the synthesis of Carbazomycin G, having unique quinone moiety, was studied against Gram-positive (Bacillus subtilis and Staphylococcus aureus) and Gram-negative (Escherichia coli and Pseudomonas sp.) bacteria. Compound 10 showed antibacterial activities against both of Escherichia coli and Staphylococcus aureus whereas compound 11 indicated the activity against Staphylococcus aureus only. Both compounds 10 and 11 exhibited minimum inhibitory concentration (MIC) of 50 μg mL(−1) against Staphylococcus aureus.
format Online
Article
Text
id pubmed-4055288
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-40552882014-06-24 Antibacterial Activity of Murrayaquinone A and 6-Methoxy-3,7-dimethyl-2,3-dihydro-1H-carbazole-1,4(9H)-dione Chakraborty, Biswanath Chakraborty, Suchandra Saha, Chandan Int J Microbiol Research Article The antibacterial activity of Murrayaquinone A (10), a naturally occurring carbazoloquinone alkaloid, and 6-methoxy-3,7-dimethyl-2,3-dihydro-1H-carbazole-1,4(9H)-dione (11), a synthetic carbazoloquinone, both obtained during the development of the synthesis of Carbazomycin G, having unique quinone moiety, was studied against Gram-positive (Bacillus subtilis and Staphylococcus aureus) and Gram-negative (Escherichia coli and Pseudomonas sp.) bacteria. Compound 10 showed antibacterial activities against both of Escherichia coli and Staphylococcus aureus whereas compound 11 indicated the activity against Staphylococcus aureus only. Both compounds 10 and 11 exhibited minimum inhibitory concentration (MIC) of 50 μg mL(−1) against Staphylococcus aureus. Hindawi Publishing Corporation 2014 2014-05-20 /pmc/articles/PMC4055288/ /pubmed/24963299 http://dx.doi.org/10.1155/2014/540208 Text en Copyright © 2014 Biswanath Chakraborty et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chakraborty, Biswanath
Chakraborty, Suchandra
Saha, Chandan
Antibacterial Activity of Murrayaquinone A and 6-Methoxy-3,7-dimethyl-2,3-dihydro-1H-carbazole-1,4(9H)-dione
title Antibacterial Activity of Murrayaquinone A and 6-Methoxy-3,7-dimethyl-2,3-dihydro-1H-carbazole-1,4(9H)-dione
title_full Antibacterial Activity of Murrayaquinone A and 6-Methoxy-3,7-dimethyl-2,3-dihydro-1H-carbazole-1,4(9H)-dione
title_fullStr Antibacterial Activity of Murrayaquinone A and 6-Methoxy-3,7-dimethyl-2,3-dihydro-1H-carbazole-1,4(9H)-dione
title_full_unstemmed Antibacterial Activity of Murrayaquinone A and 6-Methoxy-3,7-dimethyl-2,3-dihydro-1H-carbazole-1,4(9H)-dione
title_short Antibacterial Activity of Murrayaquinone A and 6-Methoxy-3,7-dimethyl-2,3-dihydro-1H-carbazole-1,4(9H)-dione
title_sort antibacterial activity of murrayaquinone a and 6-methoxy-3,7-dimethyl-2,3-dihydro-1h-carbazole-1,4(9h)-dione
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055288/
https://www.ncbi.nlm.nih.gov/pubmed/24963299
http://dx.doi.org/10.1155/2014/540208
work_keys_str_mv AT chakrabortybiswanath antibacterialactivityofmurrayaquinoneaand6methoxy37dimethyl23dihydro1hcarbazole149hdione
AT chakrabortysuchandra antibacterialactivityofmurrayaquinoneaand6methoxy37dimethyl23dihydro1hcarbazole149hdione
AT sahachandan antibacterialactivityofmurrayaquinoneaand6methoxy37dimethyl23dihydro1hcarbazole149hdione