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Maternal Obesity, Inflammation, and Developmental Programming

The prevalence of obesity, especially in women of child-bearing age, is a global health concern. In addition to increasing the immediate risk of gestational complications, there is accumulating evidence that maternal obesity also has long-term consequences for the offspring. The concept of developme...

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Detalles Bibliográficos
Autores principales: Segovia, Stephanie A., Vickers, Mark H., Gray, Clint, Reynolds, Clare M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055365/
https://www.ncbi.nlm.nih.gov/pubmed/24967364
http://dx.doi.org/10.1155/2014/418975
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author Segovia, Stephanie A.
Vickers, Mark H.
Gray, Clint
Reynolds, Clare M.
author_facet Segovia, Stephanie A.
Vickers, Mark H.
Gray, Clint
Reynolds, Clare M.
author_sort Segovia, Stephanie A.
collection PubMed
description The prevalence of obesity, especially in women of child-bearing age, is a global health concern. In addition to increasing the immediate risk of gestational complications, there is accumulating evidence that maternal obesity also has long-term consequences for the offspring. The concept of developmental programming describes the process in which an environmental stimulus, including altered nutrition, during critical periods of development can program alterations in organogenesis, tissue development, and metabolism, predisposing offspring to obesity and metabolic and cardiovascular disorders in later life. Although the mechanisms underpinning programming of metabolic disorders remain poorly defined, it has become increasingly clear that low-grade inflammation is associated with obesity and its comorbidities. This review will discuss maternal metainflammation as a mediator of programming in insulin sensitive tissues in offspring. Use of nutritional anti-inflammatories in pregnancy including omega 3 fatty acids, resveratrol, curcumin, and taurine may provide beneficial intervention strategies to ameliorate maternal obesity-induced programming.
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spelling pubmed-40553652014-06-25 Maternal Obesity, Inflammation, and Developmental Programming Segovia, Stephanie A. Vickers, Mark H. Gray, Clint Reynolds, Clare M. Biomed Res Int Review Article The prevalence of obesity, especially in women of child-bearing age, is a global health concern. In addition to increasing the immediate risk of gestational complications, there is accumulating evidence that maternal obesity also has long-term consequences for the offspring. The concept of developmental programming describes the process in which an environmental stimulus, including altered nutrition, during critical periods of development can program alterations in organogenesis, tissue development, and metabolism, predisposing offspring to obesity and metabolic and cardiovascular disorders in later life. Although the mechanisms underpinning programming of metabolic disorders remain poorly defined, it has become increasingly clear that low-grade inflammation is associated with obesity and its comorbidities. This review will discuss maternal metainflammation as a mediator of programming in insulin sensitive tissues in offspring. Use of nutritional anti-inflammatories in pregnancy including omega 3 fatty acids, resveratrol, curcumin, and taurine may provide beneficial intervention strategies to ameliorate maternal obesity-induced programming. Hindawi Publishing Corporation 2014 2014-05-20 /pmc/articles/PMC4055365/ /pubmed/24967364 http://dx.doi.org/10.1155/2014/418975 Text en Copyright © 2014 Stephanie A. Segovia et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Segovia, Stephanie A.
Vickers, Mark H.
Gray, Clint
Reynolds, Clare M.
Maternal Obesity, Inflammation, and Developmental Programming
title Maternal Obesity, Inflammation, and Developmental Programming
title_full Maternal Obesity, Inflammation, and Developmental Programming
title_fullStr Maternal Obesity, Inflammation, and Developmental Programming
title_full_unstemmed Maternal Obesity, Inflammation, and Developmental Programming
title_short Maternal Obesity, Inflammation, and Developmental Programming
title_sort maternal obesity, inflammation, and developmental programming
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055365/
https://www.ncbi.nlm.nih.gov/pubmed/24967364
http://dx.doi.org/10.1155/2014/418975
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