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Similar matrix alterations in alveolar and small airway walls of COPD patients

BACKGROUND: Remodelling in COPD has at least two dimensions: small airway wall thickening and destruction of alveolar walls. Recent studies indicate that there is some similarity between alveolar and small airway wall matrix remodelling. The aim of this study was to characterise and assess similarit...

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Autores principales: Eurlings, Irene MJ, Dentener, Mieke A, Cleutjens, Jack PM, Peutz, Carine J, Rohde, Gernot GU, Wouters, Emiel FM, Reynaert, Niki L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055380/
https://www.ncbi.nlm.nih.gov/pubmed/24886452
http://dx.doi.org/10.1186/1471-2466-14-90
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author Eurlings, Irene MJ
Dentener, Mieke A
Cleutjens, Jack PM
Peutz, Carine J
Rohde, Gernot GU
Wouters, Emiel FM
Reynaert, Niki L
author_facet Eurlings, Irene MJ
Dentener, Mieke A
Cleutjens, Jack PM
Peutz, Carine J
Rohde, Gernot GU
Wouters, Emiel FM
Reynaert, Niki L
author_sort Eurlings, Irene MJ
collection PubMed
description BACKGROUND: Remodelling in COPD has at least two dimensions: small airway wall thickening and destruction of alveolar walls. Recent studies indicate that there is some similarity between alveolar and small airway wall matrix remodelling. The aim of this study was to characterise and assess similarities in alveolar and small airway wall matrix remodelling, and TGF-β signalling in COPD patients of different GOLD stages. METHODS: Lung tissue sections of 14 smoking controls, 16 GOLD II and 19 GOLD IV patients were included and stained for elastin and collagens as well as hyaluronan, a glycosaminoglycan matrix component and pSMAD2. RESULTS: Elastin was significantly decreased in COPD patients not only in alveolar, but also in small airway walls. Interestingly, both collagen and hyaluronan were increased in alveolar as well as small airway walls. The matrix changes were highly comparable between GOLD stages, with collagen content in the alveolar wall increasing further in GOLD IV. A calculated remodelling index, defined as elastin divided over collagen and hyaluronan, was decreased significantly in GOLD II and further lowered in GOLD IV patients, suggesting that matrix component alterations are involved in progressive airflow limitation. Interestingly, there was a positive correlation present between the alveolar and small airway wall stainings of the matrix components, as well as for pSMAD2. No differences in pSMAD2 staining between controls and COPD patients were found. CONCLUSIONS: In conclusion, remodelling in the alveolar and small airway wall in COPD is markedly similar and already present in moderate COPD. Notably, alveolar collagen and a remodelling index relate to lung function.
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spelling pubmed-40553802014-06-13 Similar matrix alterations in alveolar and small airway walls of COPD patients Eurlings, Irene MJ Dentener, Mieke A Cleutjens, Jack PM Peutz, Carine J Rohde, Gernot GU Wouters, Emiel FM Reynaert, Niki L BMC Pulm Med Research Article BACKGROUND: Remodelling in COPD has at least two dimensions: small airway wall thickening and destruction of alveolar walls. Recent studies indicate that there is some similarity between alveolar and small airway wall matrix remodelling. The aim of this study was to characterise and assess similarities in alveolar and small airway wall matrix remodelling, and TGF-β signalling in COPD patients of different GOLD stages. METHODS: Lung tissue sections of 14 smoking controls, 16 GOLD II and 19 GOLD IV patients were included and stained for elastin and collagens as well as hyaluronan, a glycosaminoglycan matrix component and pSMAD2. RESULTS: Elastin was significantly decreased in COPD patients not only in alveolar, but also in small airway walls. Interestingly, both collagen and hyaluronan were increased in alveolar as well as small airway walls. The matrix changes were highly comparable between GOLD stages, with collagen content in the alveolar wall increasing further in GOLD IV. A calculated remodelling index, defined as elastin divided over collagen and hyaluronan, was decreased significantly in GOLD II and further lowered in GOLD IV patients, suggesting that matrix component alterations are involved in progressive airflow limitation. Interestingly, there was a positive correlation present between the alveolar and small airway wall stainings of the matrix components, as well as for pSMAD2. No differences in pSMAD2 staining between controls and COPD patients were found. CONCLUSIONS: In conclusion, remodelling in the alveolar and small airway wall in COPD is markedly similar and already present in moderate COPD. Notably, alveolar collagen and a remodelling index relate to lung function. BioMed Central 2014-05-26 /pmc/articles/PMC4055380/ /pubmed/24886452 http://dx.doi.org/10.1186/1471-2466-14-90 Text en Copyright © 2014 Eurlings et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Research Article
Eurlings, Irene MJ
Dentener, Mieke A
Cleutjens, Jack PM
Peutz, Carine J
Rohde, Gernot GU
Wouters, Emiel FM
Reynaert, Niki L
Similar matrix alterations in alveolar and small airway walls of COPD patients
title Similar matrix alterations in alveolar and small airway walls of COPD patients
title_full Similar matrix alterations in alveolar and small airway walls of COPD patients
title_fullStr Similar matrix alterations in alveolar and small airway walls of COPD patients
title_full_unstemmed Similar matrix alterations in alveolar and small airway walls of COPD patients
title_short Similar matrix alterations in alveolar and small airway walls of COPD patients
title_sort similar matrix alterations in alveolar and small airway walls of copd patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055380/
https://www.ncbi.nlm.nih.gov/pubmed/24886452
http://dx.doi.org/10.1186/1471-2466-14-90
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